The efficacy of traditional Chinese medicine on immune function in patients with hepatitis B-related liver fibrosis or cirrhosis: a systematic review and meta-analysis - Report - MDSpire
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Assessing the Impact of Traditional Chinese Medicine on Immune Function in Patients with Hepatitis B-Induced Liver Fibrosis or Cirrhosis: A Systematic Review and Meta-Analysis
Clinical Report: Impact of Traditional Chinese Medicine on Immune Function in Hepatitis B
Overview
This systematic review and meta-analysis evaluated the effects of Traditional Chinese Medicine (TCM) combined with nucleos(t)ide analogs (NAs) on immune function in patients with hepatitis B-related liver fibrosis or cirrhosis. Improvements in various immune cell metrics and liver function indexes were reported, but the quality of evidence was classified as low.
Background
Hepatitis B virus (HBV) infection is a significant global health issue, affecting approximately 250 million people and often leading to liver fibrosis and cirrhosis. Current treatments primarily focus on managing HBV without effectively reversing liver damage.
Data Highlights
Outcome
Mean Difference (MD)
95% Confidence Interval (CI)
p-value
CD3 +
5.83
(3.93, 7.73)
< 0.00001
CD4 +
4.32
(3.56, 5.08)
< 0.00001
CD4+/CD8 +
0.24
(0.18, 0.29)
< 0.00001
CD8 +
-2.67
(-3.46, -1.89)
< 0.00001
Key Findings
25 RCTs involving 2,585 patients were included in the analysis.
TCM combined with NAs improved immune cell metrics, including CD3 +, CD4 +, and NK cells.
TCM decreased CD8 + cells and various cytokines, including IL-6 and TNF-α.
Improvements in liver function indexes such as ALT, AST, and bilirubin were observed.
The certainty of evidence for immune function and liver fibrosis indexes was classified as low.
Clinical Implications
The combination of TCM and NAs may enhance immune function and liver health in patients with hepatitis B-related liver fibrosis or cirrhosis.
Conclusion
The integration of TCM with standard antiviral therapy may improve immune and liver function in hepatitis B patients, but further research is necessary.
