Correction: Interleukin−6 in complications of prematurity: from biomarker to targeted therapy - Report - MDSpire
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

Correction: The Role of Interleukin−6 in Prematurity Complications: Transitioning from Biomarker to Therapeutic Target

  • By

  • Shuzhe Xiao

  • Qi Zheng

  • Lingling Wang

  • Zhiqiu Wang

  • Guangliang Bi

  • Jie Yang

  • September 10, 2026

Share

Correction: The Role of Interleukin−6 in Prematurity Complications

Overview

This correction addresses errors in the reporting of interleukin−6 (IL−6) as a biomarker for complications associated with prematurity. Key updates include corrections to Table 1 and textual errors in the manuscript, specifically regarding the description of IL−6's role in various complications.

Background

Complications from prematurity significantly impact the health of preterm infants, contributing to high mortality rates and long-term health issues. Interleukin−6 (IL−6) is implicated in various neonatal complications.

Data Highlights

ComplicationIL−6 AUCCI
Neonatal Septicemia0.8895% CI

Key Findings

  • IL−6 levels are elevated in several complications associated with prematurity, including BPD, NES, ROP, AKI, NEC, and HIE.
  • In a cohort study, cord blood IL−6 predicted early-onset neonatal sepsis more effectively than CRP.
  • IL−6 thresholds for diagnosing sepsis in preterm infants remain undefined.
  • Corrections were made to the description of IL−6's role in ROP and other sections of the manuscript.

Clinical Implications

Understanding the precise role of IL−6 could inform future research on complications associated with prematurity.

Conclusion

The corrections made in this publication clarify the role of IL−6 in prematurity complications.

Related Resources & Content

  1. Xiao S, Zheng Q, Wang L, Wang Z, Bi G, Yang J, Front Pediatr, 2026 -- Correction: The Role of Interleukin−6 in Prematurity Complications
  2. the pathologist — Interleukin-6 in the Fight Against Sepsis
  3. Frontiers in Pediatrics — Diminished Activity of NLRP3, AIM2, and NLRC4 Inflammasomes in the Cord Blood of Infants Born Extremely Preterm
  4. Acta Paediatrica — Elevated Serum Neurofilament Light Chain Is Associated With Systemic Inflammation in Very Preterm Infants
  5. Frontiers in Pediatrics — Diagnostic performance of interleukin-27 and C-reactive protein in neonatal sepsis: an updated systematic review and meta-analysis
  6. Surviving Sepsis Campaign International Guidelines for the Management of Sepsis and Septic Shock in Children 2026
  7. Diagnostic accuracy of interleukin-6 (IL-6) as a significant biomarker in late-onset neonatal sepsis
  8. Recommendations and evidence - WHO recommendations for management of serious bacterial infections in infants aged 0–59 days - NCBI Bookshelf
  9. Toward a Harmonized Bronchopulmonary Dysplasia Definition: An International Delphi Process | Pediatrics | American Academy of Pediatrics
  10. The Management of Neonatal Sepsis and Septic Shock | Current Treatment Options in Pediatrics | Springer Nature Link
  11. pubmed.ncbi.nlm.nih.gov
  12. Diagnostic Value of Umbilical Cord Blood Interleukin-6 Level in Premature Infants with Early-Onset Sepsis - PMC
  13. Interleukin-6 in complications of prematurity: from biomarker to targeted therapy.
  14. DailyMed - TYENNE- tocilizumab-aazg injection, solution
  15. Study Details | NCT07254000 | Anakinra Pilot 2 - A Study to Optimise Dose and Route of Administration of Anakinra in Preterm Infants | ClinicalTrials.gov

Original Source(s)

Related Content