Prevalence of cognitive frailty in older adults with stroke in China: a systematic review and meta-analysis - Report - MDSpire

Prevalence of cognitive frailty in older adults with stroke in China: a systematic review and meta-analysis

  • By

  • Yang Li

  • Zhiyuan Zhang

  • Yonghua Cai

  • Yutong Cui

  • Xuewei Zhan

  • Xiaoxing Lai

  • Xiaopeng Huo

  • Donglei Shi

  • July 8, 2026

  • 0 min

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Clinical Report: The Frequency of Cognitive Frailty Among Elderly Stroke Patients in China

Overview

This systematic review and meta-analysis evaluates the prevalence of cognitive frailty (CF) among older adults with stroke in China, revealing a pooled prevalence of 33%. Factors such as age, alcohol consumption, malnutrition, and depression significantly influence CF prevalence.

Background

Cognitive frailty is a critical syndrome that combines physical frailty and mild cognitive impairment, particularly relevant in the context of stroke recovery. As the aging population in China grows, understanding CF's prevalence and associated factors is essential.

Data Highlights

CharacteristicPrevalence
Overall CF Prevalence33% (95% CI: 28–39%)
CF in Patients ≥80 yearsHigher than 60–79 years (p < 0.05)
CF in Alcohol ConsumersHigher than Non-consumers (p < 0.05)
CF in Malnutrition47% (95% CI: 34–60%)
CF in Depression62% (95% CI: 53–71%)

Key Findings

  • The pooled prevalence of cognitive frailty among older adults with stroke in China is 33%.
  • Patients aged ≥80 years show a significantly higher prevalence of cognitive frailty compared to those aged 60–79 years.
  • Alcohol consumption is associated with a higher prevalence of cognitive frailty.
  • Malnutrition and depression are linked to particularly high prevalence rates of cognitive frailty at 47% and 62%, respectively.
  • There is a need for larger studies to confirm these findings due to the limited evidence base and high heterogeneity.

Clinical Implications

Clinicians should be aware of the prevalence of cognitive frailty in older stroke patients, particularly among those with malnutrition and depression.

Conclusion

The findings indicate the prevalence of cognitive frailty among older stroke patients in China.

Related Resources & Content

  1. Frontiers in Cardiovascular Medicine, 2026 -- Prevalence and risk factors of cognitive impairment in patients with coronary heart disease: a systematic review and meta-analysis
  2. Frontiers in Medicine, 2026 -- Analysis of factors associated with cognitive impairment in elderly patients hospitalized with chronic heart failure
  3. Frontiers in Neurology, 2026 -- Prevalence of anxiety and depression in young stroke patients, and associated factors: a meta-analysis
  4. Cognitive Impairment Following Ischemic and Hemorrhagic Stroke: A Scientific Statement from the American Heart Association/American Stroke Association - PMC, 2023
  5. Prevalence and determinants of cognitive impairment in older adults with stroke in China: a systematic review - PMC, 2023
  6. Frontiers in Medicine — Impact of frailty on post-procedural adverse outcomes in older adults aged ≥75 years undergoing percutaneous coronary intervention: a systematic review of observational studies
  7. Cognitive Impairment Following Ischemic and Hemorrhagic Stroke: A Scientific Statement from the American Heart Association/American Stroke Association - PMC
  8. Prevalence and determinants of cognitive impairment in older adults with stroke in China: a systematic review - PMC

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