Laparoscopic sleeve gastrectomy in adults with Prader-Willi syndrome and super-morbid obesity: a case report and literature review - Report - MDSpire

Laparoscopic sleeve gastrectomy in adults with Prader-Willi syndrome and super-morbid obesity: a case report and literature review

  • By

  • Ji Li

  • Linhua Hao

  • Yuan-Hui Jiang

  • Lei Chen

  • June 15, 2026

  • 0 min

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Clinical Report: Laparoscopic Sleeve Gastrectomy in Adults with Prader-Willi Syndrome

Overview

This report evaluates the safety and outcomes of laparoscopic sleeve gastrectomy (LSG) in a 24-year-old male with Prader-Willi syndrome (PWS) and super-morbid obesity. The findings suggest that while LSG may provide modest weight loss, significant postoperative management challenges persist, necessitating careful patient selection and multidisciplinary support.

Background

Prader-Willi syndrome (PWS) is a genetic disorder characterized by severe obesity and hyperphagia, complicating weight management efforts. Traditional interventions often fail, leading to consideration of bariatric surgery such as LSG. Understanding the safety and efficacy of LSG in this unique population is crucial for optimizing treatment strategies and improving patient outcomes.

Data Highlights

No numerical data or trial data was provided in the article.

Key Findings

  • A 24-year-old male with PWS and a BMI of 64.44 kg/m² underwent LSG.
  • Short-term postoperative recovery was uneventful, but long-term outcomes remain uncertain.
  • LSG was associated with modest weight reduction in patients with PWS, but significant postoperative management challenges were noted.
  • Behavioral issues and nutritional monitoring requirements complicate postoperative care.
  • LSG should not be a first-line intervention for PWS; careful patient selection is essential.

Clinical Implications

Healthcare providers should approach LSG for patients with PWS cautiously, ensuring comprehensive multidisciplinary evaluations are conducted. Ongoing support and monitoring are critical to address the unique challenges posed by this patient population.

Conclusion

While LSG may offer some benefits for weight management in adults with PWS, its application should be limited to carefully selected cases, emphasizing the need for robust postoperative support and management strategies.

Related Resources & Content

  1. Alqahtani et al., Frontiers in Surgery, 2026 -- Case Report: Single-incision laparoscopic sleeve gastrectomy plus jejunojejunal bypass for the treatment of type 2 diabetes in patients with obesity: a case series and review
  2. Updates in Surgery, 2026 -- Omentopexy after laparoscopic sleeve gastrectomy in children and adolescents: is it effective in reducing post-operative complications?
  3. Obesity Surgery, 2026 -- Robotic-Assisted Single Anastomosis Duodeno-Ileal Bypass with Sleeve Gastrectomy – A Systematic Review
  4. Obesity Surgery, 2022 -- Efficacy and Safety of Laparoscopic Sleeve Gastrectomy for Weight Management in Individuals with Mild Obesity: A 3-Year Prospective Cohort Analysis
  5. ASMBS/IFSO, 2022 -- Indications for Metabolic and Bariatric Surgery
  6. ScienceDirect, 2023 -- Metabolic and bariatric surgery for obesity in Prader Willi syndrome: systematic review and meta-analysis
  7. 2022 American Society for Metabolic and Bariatric Surgery (ASMBS) and International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO): Indications for Metabolic and Bariatric Surgery
  8. Metabolic and bariatric surgery for obesity in Prader Willi syndrome: systematic review and meta-analysis - ScienceDirect

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