Assessment of Safety and Effectiveness of Combined Platelet-Rich Plasma and Hyaluronic Acid Therapy for Neck Rejuvenation in Thailand: A Prospective Investigation - Report - MDSpire

Assessment of Safety and Effectiveness of Combined Platelet-Rich Plasma and Hyaluronic Acid Therapy for Neck Rejuvenation in Thailand: A Prospective Investigation

  • By

  • Stephanie T. de Leon

  • Diandra A. Zabala

  • Noldtawat Viriyaskultorn

  • Panyapat Buranaporn

  • Woramate Bhorntarakcharoen

  • Thrit Hutachoke

  • Thanyaporn Leesanguankul

  • Teerapat Wannawittayapa

  • Wetch Tantrapongsathorn

  • Sariya Sittiwanaruk

  • Rungsima Wanitphakdeedecha

  • January 11, 2026

  • 0 min

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Clinical Report: Assessment of PRP and Hyaluronic Acid for Neck Rejuvenation

Overview

Revise to specify the degree of improvement in hydration, melanin, and erythema.

Background

Neck aging is a significant aesthetic concern, yet effective nonsurgical treatments are limited. The combination of PRP and HA offers a potential solution due to their synergistic regenerative properties. This study aims to fill the gap in research regarding the effectiveness of this combination specifically for neck rejuvenation.

Data Highlights

Adjust the table to include specific numerical values for 'significant' improvements.

Key Findings

  • Significant improvement in skin firmness observed, with up to 65% enhancement at 6 months.
  • Notable increases in skin hydration and reductions in melanin and erythema.
  • No severe adverse effects reported during the study period.
  • Modest outcomes noted for skin elasticity, wrinkles, texture, and brightness.
  • Study highlights the need for further controlled trials to validate findings.

Clinical Implications

The findings suggest that PRP-HA therapy is a relatively safe and effective minimally invasive option for neck rejuvenation. Clinicians may consider this combination treatment for patients seeking non-surgical aesthetic improvements in neck appearance.

Conclusion

PRP-HA therapy shows promise as a viable treatment for neck rejuvenation, although further research is necessary to establish standardized protocols and outcomes.

References

  1. Clinical Rheumatology, 2020 -- Evaluation of Short-Term Outcomes from Single-Dose Intra-Articular Peptide Compared to Hyaluronic Acid and Platelet-Rich Plasma Injections in Knee Osteoarthritis: A Randomized Trial
  2. Knee Surgery, Sports Traumatology, Arthroscopy, 2013 -- Intra-Articular Applications of Platelet-Rich Plasma: A Comprehensive Review of Preclinical and Clinical Evidence for Joint Degeneration Management
  3. Knee Surgery, Sports Traumatology, Arthroscopy, 2014 -- Impact of Two Distinct Platelet-Rich Plasma Formulations on Synoviocyte Behavior
  4. Clinical Rheumatology, 2025 -- Evaluation of the Safety and Efficacy of Intra-Articular High-Purity Sodium Hyaluronate Injections in Knee Osteoarthritis Patients: Results from a 28-Week Post-Market Clinical Follow-Up
  5. Dermatologic Surgery, 2024 -- Consensus Agreements on Regenerative Aesthetics
  6. Aesthetic Surgery Journal Open Forum, 2024 -- Efficacy and Safety of Hyaluronic Acid Fillers for Horizontal Neck Lines: A Systematic Review and Meta-Analysis
  7. Aesthetic Surgery Journal Open Forum, 2024 -- Meta-Analysis of the Efficacy of Platelet-Rich Plasma in Treating Skin Aging
  8. Dermatologic Surgery
  9. Efficacy and Safety of Hyaluronic Acid Fillers for Horizontal Neck Lines: A Systematic Review and Meta-Analysis | Aesthetic Surgery Journal Open Forum | Oxford Academic
  10. Meta-Analysis of the Efficacy of Platelet-Rich Plasma in Treating Skin Aging | Aesthetic Surgery Journal Open Forum | Oxford Academic

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