Digital twins in healthcare: A systematic review of current applications, frameworks, and future directions - Report - MDSpire

Digital twins in healthcare: A systematic review of current applications, frameworks, and future directions

  • By

  • Valeria Calcaterra

  • Luca Guardamagna

  • Alessandro Gatti

  • Virginia Rossi

  • Pamela Patanè

  • Luca Marin

  • Matteo Vandoni

  • Gianvincenzo Zuccotti

  • June 23, 2026

  • 0 min

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Clinical Report: Exploring Digital Twins in Medicine: A Comprehensive Review

Overview

This systematic review assesses the current applications of digital twins (DTs) in healthcare, focusing on their role in personalized health management.

Background

Digital twins enable real-time monitoring and personalized treatment strategies. Their ability to create virtual representations of patients facilitates predictive modeling.

Data Highlights

No numerical data or trial results were provided in the source material.

Key Findings

  • Digital twins can support decision-making and optimize treatment strategies in healthcare.
  • They enable modeling of individual patients by integrating multimodal data sources.
  • Applications of DTs include chronic disease management, surgical planning, and rehabilitation.
  • DTs promote integrated clinical management by enhancing information sharing among specialists.
  • Challenges in integrating DTs into clinical practice include data integration and model fidelity.

Clinical Implications

Addressing the challenges related to data integration and model accuracy is essential for the effective use of digital twins.

Conclusion

Digital twins have potential applications in healthcare, but further exploration and refinement of this technology are necessary.

Related Resources & Content

  1. Frontiers in Digital Health, 2026 -- Human digital twins in personalized and predictive healthcare: a comprehensive review of technologies, applications, and future directions
  2. npj Digital Medicine, 2025 -- An Overview of Human Digital Twin Applications and Usage Trends in Healthcare
  3. npj Digital Medicine, 2025 -- The role of digital twins in P4 medicine: A paradigm for modern healthcare
  4. Frontiers in Oncology, 2026 -- Digital Twins as catalysts for Whole Person Health Mind Body Medicine in Integrative Oncology
  5. National Academies, 2025 -- Definitions and clinical consensus on digital twins
  6. FDA, 2023 -- Assessing the Credibility of Computational Modeling and Simulation in Medical Device Submissions
  7. npj Digital Medicine, 2025 -- Human-machine co-adaptation to automated insulin delivery: a randomised clinical trial using digital twin technology
  8. https://nap.nationalacademies.org/resource/26894/RH-digital-twins.pdf
  9. Assessing the Credibility of Computational Modeling and Simulation in Medical Device Submissions | FDA
  10. Human-machine co-adaptation to automated insulin delivery: a randomised clinical trial using digital twin technology | npj Digital Medicine

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