A Retrospective Analysis of the Surgical Efficacy for Tophi Wounds in Hainan Province - Report - MDSpire

A Retrospective Analysis of the Surgical Efficacy for Tophi Wounds in Hainan Province

  • By

  • Xiao, Weihao

  • Ming, Xingchen

  • Huang, Yuxi

  • Li, Jiaxuan

  • Jiao, Qiqi

  • Yang, Jian

  • Zheng, Linyang

  • Zeng, Yunfu

  • Wang, Rong

  • Cheng, Shaowen

  • Bian, Yangyang

  • Yao, Jiangling

  • April 13, 2026

  • 0 min

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Clinical Report: Surgical Outcomes for Gouty Tophi Wounds in Hainan Province

Overview

This retrospective study analyzed surgical outcomes in 130 patients with gouty tophi wounds, revealing a high wound healing rate of 95.38% and significant reductions in infection markers postoperatively. The findings underscore the importance of surgical intervention combined with urate-lowering therapy for optimal patient outcomes.

Background

Gouty tophi can lead to significant morbidity, particularly in older males with multiple comorbidities. Understanding surgical outcomes and perioperative management is crucial for improving care in this patient population. The rising incidence of gout necessitates effective treatment strategies to mitigate complications associated with tophi.

Data Highlights

ParameterPreoperativePostoperative
Wound Healing RateN/A95.38%
Mean Healing Time (days)N/A31.43 ± 16.18
Positive Culture Rate16.15%0.77%
WBC CountN/ASignificant Reduction (P < 0.05)
Neutrophil CountN/ASignificant Reduction (P < 0.001)

Key Findings

  • The study included 130 patients, predominantly male (99.2%), with a mean age of 58.15 years.
  • Common comorbidities included hypertension (43.85%) and diabetes mellitus (13.85%).
  • Surgical modalities included lesion excision (41.54%), debridement (34.62%), and vacuum sealing drainage (23.08%).
  • Postoperative pain scores significantly decreased (P < 0.001) across assessment scales.
  • Only 3.85% of cases failed to heal, with one patient dying from multiorgan failure.

Clinical Implications

The findings suggest that surgical intervention for gouty tophi wounds is effective in achieving high healing rates and reducing infection markers. Clinicians should consider combining surgical treatment with urate-lowering therapy to enhance patient outcomes and minimize complications.

Conclusion

Surgical treatment of gouty tophi wounds demonstrates favorable outcomes, particularly when integrated with medical management strategies. Continued research is essential to refine perioperative care and optimize recovery in this patient population.

References

  1. Clinical Rheumatology, 2025 -- Economic Impact and Comorbid Conditions in Hospitalized Gout Patients in Guangdong Province
  2. Hernia, 2025 -- Comparative Outcomes of Open Preperitoneal and Laparoscopic Approaches in Ambulatory Bilateral Groin Hernia Repair
  3. Clinical Rheumatology, 2022 -- Identifying Risk Factors for Septic Arthritis and the Outcomes of Multiple Arthroscopic Washouts: A Two-Year Follow-Up Study at a Major Trauma Center
  4. 2024 Update of Chinese Guidelines for Diagnosis and Treatment of Hyperuricemia and Gout Part I: Recommendations for General Patients - PMC
  5. Updates in Surgery — The complexity of laparoscopic hepatectomy in hepatocellular carcinoma is linked to long-term patient outcomes
  6. Results of phase III MIRROR trial of Krystexxa in gout published in Arthritis & Rheumatology
  7. 2024 Update of Chinese Guidelines for Diagnosis and Treatment of Hyperuricemia and Gout Part I: Recommendations for General Patients - PMC

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