Association between the fibrosis-4 index and carotid atherosclerosis in Chinese patients with type 2 diabetes mellitus: a cross-sectional study - Report - MDSpire
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Association between the fibrosis-4 index and carotid atherosclerosis in Chinese patients with type 2 diabetes mellitus: a cross-sectional study
Clinical Report: Relationship between the Fibrosis-4 Index and Carotid Atherosclerosis
Overview
This study investigates the association between the fibrosis-4 (FIB-4) index and carotid atherosclerosis (CAS) in Chinese individuals with type 2 diabetes mellitus (T2DM). Higher FIB-4 levels correlate with increased odds of CAS.
Background
Carotid atherosclerosis (CAS) is a significant marker for cardiovascular events, particularly in patients with type 2 diabetes mellitus (T2DM). The fibrosis-4 (FIB-4) index serves as a noninvasive tool for assessing liver fibrosis, which has been linked to cardiovascular risks.
Data Highlights
FIB-4 Quartile
Odds Ratio for CAS (95% CI)
Lowest
Reference
Second
1.16 (0.79–1.72)
Third
1.75 (1.19–2.58)
Fourth
2.04 (1.39–3.00)
Key Findings
Higher FIB-4 levels are associated with increased odds of carotid atherosclerosis (CAS).
In the fully adjusted model, odds ratios for CAS increase with higher FIB-4 quartiles.
RCS analysis indicates a nonlinear relationship between FIB-4 and CAS risk.
FIB-4 shows limited discriminatory performance for CAS with an AUC of 0.579.
Similar associations were found for lower extremity arterial disease (LEAD) and diabetic peripheral neuropathy (DPN).
Clinical Implications
FIB-4 may be utilized as a marker for assessing the risk of macrovascular complications in patients with T2DM.
Conclusion
The study highlights the significant association between elevated FIB-4 levels and increased risks of CAS and LEAD in patients with T2DM.
