The association between activity patterns and malignant neoplasms of female genital organs: a prospective cohort study of UK biobank - Report - MDSpire

The association between activity patterns and malignant neoplasms of female genital organs: a prospective cohort study of UK biobank

  • By

  • Xuebing Li

  • Hang Yu

  • Yubing Teng

  • Huanyu Guo

  • Yuqing Liu

  • Dandan Zhang

  • Tianshu Han

  • May 25, 2026

  • 0 min

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Clinical Report: Investigating the Link Between Physical Activity Patterns and Malignant Tumors in Female Reproductive Organs

Overview

This study examines the association between physical activity timing and the risk of malignant neoplasms in female reproductive organs.

Background

This study aims to fill the gap in existing literature regarding the timing of physical activity and its impact on cancer incidence.

Data Highlights

GroupHazard Ratio (HR)95% Confidence Interval (CI)
Evening1.5301.006–2.326
Mixed-time1.4061.026–1.928

Key Findings

  • 419 incident cases of malignant neoplasms were recorded during a median follow-up of 12.6 years.
  • Evening physical activity was associated with a significantly higher risk of reproductive system malignancies (HR = 1.530).
  • Mixed-time physical activity also showed an elevated risk (HR = 1.406).
  • No significant associations were found for the midday-afternoon group.
  • No statistically significant associations were observed between activity patterns and specific types of female genital organ malignancies.

Clinical Implications

The findings indicate an association between the timing of physical activity and the risk of developing malignant neoplasms in female reproductive organs.

Conclusion

Engaging in moderate-to-vigorous physical activity during the evening or at mixed times is associated with an increased risk of malignant neoplasms of the female reproductive system compared to morning activity.

Related Resources & Content

  1. Timmins et al, Journal of Clinical Oncology, 2024 -- Leisure-Time Physical Activity and Breast Cancer Risk in Premenopausal Women
  2. Physical Activity Trends and Their Impact on Gastrointestinal Cancer Risk, The New Gastroenterologist, 2025
  3. Investigating the Link Between Longitudinal Measurements of Nondense Breast Tissue and Breast Cancer Risk, American Journal of Epidemiology, 2024
  4. Link Between Accelerometer-Recorded Physical Activity Levels and Overall as well as Cause-Specific Mortality in Patients with Cardiovascular Disease, European Journal of Preventive Cardiology, 2024
  5. Physical activity, World Health Organization, 2024
  6. Association between physical activity and gynecological cancers: a meta-analysis of prospective cohort studies, BMC Women's Health, 2025
  7. Associations of adiposity and device-measured physical activity with cancer incidence: UK Biobank prospective cohort study, UK Biobank, 2024
  8. Physical activity
  9. Association between physical activity and gynecological cancers: a meta-analysis of prospective cohort studies | BMC Women's Health | Springer Nature Link
  10. Associations of adiposity and device-measured physical activity with cancer incidence: UK Biobank prospective cohort study - UK Biobank

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