Case Report: Spectral CT characterization of giant esophageal schwannoma with reactive lymphoid hyperplasia mimicking lymphoproliferative disease - Report - MDSpire

Case Report: Spectral CT characterization of giant esophageal schwannoma with reactive lymphoid hyperplasia mimicking lymphoproliferative disease

  • By

  • Zuyi Fan

  • Anqi Zhang

  • Yumeng Xi

  • Meng Wang

  • Zhenzhen Fan

  • Zhihui Dong

  • July 3, 2026

  • 0 min

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Clinical Report: Spectral CT Analysis of a Large Esophageal Schwannoma

Overview

This case study presents a 48-year-old woman with a large esophageal schwannoma, highlighting the challenges in preoperative diagnosis due to overlapping imaging characteristics with other tumors. Spectral CT provided imaging capabilities that aided in the characterization of the tumor and associated lymphoid hyperplasia.

Background

Esophageal schwannomas are rare benign tumors that can be difficult to diagnose preoperatively due to their similarity in appearance to other submucosal tumors. Accurate diagnosis is crucial as these tumors can mimic more aggressive conditions.

Data Highlights

MeasurementValue
Mass Size83 × 63 × 100 mm
Imaging TechniqueSpectral CT

Key Findings

  • The patient presented with mild dysphagia and an incidentally detected mediastinal mass.
  • Spectral CT revealed a large submucosal mass with heterogeneous enhancement and an air crescent sign.
  • Histopathology confirmed a spindle-cell tumor consistent with schwannoma, with a reactive lymphoid cuff.
  • Immunohistochemical profiling showed positivity for S-100 and vimentin, aiding in the diagnosis.
  • The tumor was managed with partial esophagectomy and targeted adjuvant radiotherapy due to incomplete resection.

Clinical Implications

Clinicians should consider advanced imaging modalities when evaluating submucosal esophageal masses.

Conclusion

The integration of spectral CT in the diagnostic process for esophageal schwannomas can enhance characterization and inform treatment strategies.

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  2. MRI Characteristics of CNS Large B-cell Lymphoma: An Analysis of Susceptibility and T2*-weighted Imaging in a Large Cohort from a Single Center, Journal of Neuro-Oncology, 2025 -- Title
  3. Characteristics and Prognostic Outcomes of Histiocytic Neoplasms in the Central Nervous System, Blood Cancer Journal, 2024 -- Title
  4. ACR Appropriateness Criteria® Imaging of Mediastinal Masses - ScienceDirect, 2021 -- Title
  5. Understanding Delays in Diagnosis and Treatment of Primary Central Nervous System Lymphoma: Insights for Neurosurgeons
  6. Benign Esophageal Tumors - Oncology - Merck Manual Professional Edition
  7. ACR Appropriateness Criteria® Imaging of Mediastinal Masses - ScienceDirect
  8. Frontiers | Case Report: Coexistence of an esophageal schwannoma disguised as a leiomyoma with a gastrointestinal stromal tumor of the gastric fundus

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