Diagnostic value of peroral choledochoscopy combined with modified biopsy forceps for malignant biliary strictures: a two-center retrospective study - Report - MDSpire

Diagnostic value of peroral choledochoscopy combined with modified biopsy forceps for malignant biliary strictures: a two-center retrospective study

  • By

  • Geqi Zhu

  • Yu Jin

  • Cuihua Qi

  • Shuxin Tian

  • Hao Liu

  • Weigang Chen

  • Rong Lin

  • Guochen Shang

  • June 18, 2026

  • 0 min

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Clinical Report: Evaluating the Diagnostic Utility of Peroral Choledochoscopy

Overview

This study evaluates the diagnostic value and safety of peroral cholangioscopy (POCS) combined with modified biopsy forceps for malignant biliary strictures (MBS).

Background

Biliary strictures can lead to obstructed bile flow and cholestasis, often resulting in significant clinical consequences. Differentiating between benign and malignant biliary strictures is crucial, as misdiagnosis can lead to unnecessary surgical interventions. Current diagnostic methods, including ERCP, face challenges in obtaining sufficient tissue samples, highlighting the need for improved techniques.

Data Highlights

GroupDiagnostic AccuracySensitivity
POCS GroupData not providedData not provided
POCS with Modified Biopsy ForcepsData not providedData not provided

Key Findings

  • POCS allows for direct visualization of the bile duct, improving biopsy precision.
  • Modified biopsy forceps enhance the diagnostic accuracy for MBS.
  • Misdiagnosis of biliary strictures can lead to unnecessary surgical interventions.
  • Approximately 15% to 24% of patients with suspected MBS are confirmed to have benign strictures post-surgery.
  • Cholangiocarcinoma is the most common cause of malignant biliary strictures.

Clinical Implications

This study evaluates the diagnostic capabilities for MBS.

Conclusion

This study evaluates the use of POCS with modified biopsy forceps for the diagnosis of malignant biliary strictures.

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  8. American Society for Gastrointestinal Endoscopy guideline on the role of endoscopy in the diagnosis of malignancy in biliary strictures of undetermined etiology: summary and recommendations
  9. Endoscopic and novel approaches for evaluation of indeterminate biliary strictures - ScienceDirect
  10. Effectiveness of cholangioscopy guided biopsy versus ERCP guided brushings in diagnosing malignant biliary strictures - PubMed
  11. Digital single-operator cholangioscopy-guided biopsy for indeterminate biliary strictures: Seeing is believing? - Gastrointestinal Endoscopy
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  15. Study Details | NCT07620080 | EYEMAX® Versus SPYGLASS™ DS for Biliary Stricture Diagnosis | ClinicalTrials.gov
  16. The SMART-AI trial: Real-time cholangioscopy artificial intelligence for the classification of biliary strictures | medRxiv

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