Intravesical hyaluronic acid and chondroitin sulphate for recurrent urinary tract infections: a prospective multicentre comparison of two instillation protocols - Report - MDSpire
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Comparative Analysis of Two Instillation Protocols of Intravesical Hyaluronic Acid and Chondroitin Sulphate for Women with Recurrent Urinary Tract Infections: A Prospective Multicenter Study
Clinical Report: Comparative Analysis of Two Instillation Protocols of Intravesical Hyaluronic Acid and Chondroitin Sulphate for Women with Recurrent Urinary Tract Infections
Overview
This study evaluated the safety and effectiveness of two different protocols for intravesical hyaluronic acid and chondroitin sulphate in women with recurrent urinary tract infections (r-UTIs). Both protocols significantly reduced UTI recurrence and improved urinary symptoms over 12 months, although no significant differences were observed between the two groups.
Background
Recurrent urinary tract infections (r-UTIs) are prevalent among women and significantly impact their quality of life and healthcare resources. Traditional antibiotic prophylaxis has limitations, including the risk of antimicrobial resistance. Intravesical administration of glycosaminoglycans (GAGs) like hyaluronic acid and chondroitin sulphate offers a non-antibiotic alternative, yet optimal administration protocols remain undefined.
Data Highlights
Group
Mean UTI Frequency (12 months)
p-value
Group A
0.6 ± 0.5
-
Group B
0.7 ± 0.3
p > 0.05
Key Findings
140 women with r-UTIs were enrolled, with 70 in each treatment group.
Both groups showed significant improvements in urinary symptoms and pelvic pain (p < 0.001).
No serious adverse events were reported during the study.
UF parameters and PVR remained stable throughout the study.
Clinical outcomes did not differ significantly between the two treatment protocols.
Clinical Implications
The study presents findings on the use of intravesical HA + CS for r-UTIs in women, noting that both evaluated protocols demonstrated similar efficacy in reducing UTI recurrence and improving symptoms.
Conclusion
Intravesical administration of hyaluronic acid and chondroitin sulphate effectively reduces UTI recurrence and improves urinary symptoms in women, with no significant differences between the two instillation protocols assessed.
