Clinical outcomes of Impella 5+ in acute myocardial infarction-related cardiogenic shock: a retrospective single-center study - Report - MDSpire

Outcomes Associated with Impella 5+ in Patients Experiencing Cardiogenic Shock Due to Acute Myocardial Infarction: A Retrospective Study from a Single Center

  • By

  • Giulia Maj

  • Alberto Piermartiri

  • Serena Querio

  • Marta Bandini

  • Marco Lombardi

  • Edoardo Elia

  • Serena Penpa

  • Riccardo Mazzucco

  • Federico Pappalardo

  • Corrado Cavozza

  • Alina Gallo

  • Andrea Audo

  • Giuseppe Patti

  • Gioel Gabrio Secco

  • July 21, 2026

Share

Clinical Report: Outcomes Associated with Impella 5+ in Cardiogenic Shock

Overview

This study evaluates the use of Impella 5+ in patients with acute myocardial infarction-related cardiogenic shock, reporting a survival rate of 79% during hospitalization.

Background

Cardiogenic shock (CS) complicating acute myocardial infarction (AMI) is associated with high mortality rates, despite advances in treatment. Temporary mechanical circulatory support (t-MCS) devices like Impella have emerged as potential therapeutic options. However, evidence regarding the larger Impella 5+ device in this context remains limited, necessitating further investigation.

Data Highlights

ParameterValue
Patients treated28
Median inotropic score10.5
Median left ventricular ejection fraction17.5%
Length of support8 days
Overall survival rate79%
Major bleeding complications1 patient (7%)

Key Findings

  • Impella 5+ was used in 28 patients with AMI-related cardiogenic shock.
  • 79% of patients survived to discharge during the index hospitalization.
  • 12 patients required concomitant ECMO support (ECPella).
  • Median length of support with Impella 5+ was 8 days.
  • Only 1 patient experienced a major bleeding complication.

Clinical Implications

Further studies are warranted to confirm these findings in larger cohorts.

Conclusion

Impella 5+ was associated with a survival rate of 79% during hospitalization.

Related Resources & Content

  1. Author(s)/Org, Source, Year -- Outcomes following coronary artery bypass grafting with temporary left ventricular assist device support
  2. Author(s)/Org, Source, Year -- A local complication-prevention pathway for Impella-supported cardiogenic shock: a single-center experience
  3. Author(s)/Org, Source, Year -- Evaluation of Mechanical Circulatory Support: A Propensity-Matched Study of Venoarterial Extracorporeal Membrane Oxygenation versus Impella in Patients Experiencing Cardiogenic Shock
  4. Author(s)/Org, Source, Year -- 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes
  5. Author(s)/Org, Source, Year -- Microaxial Flow Pump in Infarct-Related Cardiogenic Shock
  6. Clinical Research in Cardiology — Enhanced Microcirculation in Acute ST-Elevation Myocardial Infarction Patients Receiving the Impella LP2.5 Percutaneous Left Ventricular Assist Device
  7. 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines
  8. Microaxial Flow Pump in Infarct-Related Cardiogenic Shock - American College of Cardiology
  9. Outcomes of patients supported on Impella 5.5 for more than 14 days: A Cardiogenic Shock Working Group registry analysis - ScienceDirect
  10. Impella 5.5 Support in Severe Cardiogenic Shock: Outcomes From the First Spanish Multicentre Cohort in Heart Transplant Centres - PMC

Original Source(s)

Clinical outcomes of Impella 5+ in acute myocardial infarction-related cardiogenic shock: a retrospective single-center study

  • by Giulia Maj, Alberto Piermartiri, Serena Querio, Marta Bandini, Marco Lombardi, Edoardo Elia, Serena Penpa, Riccardo Mazzucco, Federico Pappalardo, Corrado Cavozza, Alina Gallo, Andrea Audo, Giuseppe Patti, Gioel Gabrio Secco

  • July 21, 2026

Related Content

Predictive value of the serum sodium to log(D-dimer) ratio for the risk of all-cause death in patients with chronic heart failure with different ejection fractions

Differential age-related patterns in the associations of LDL-C, TG/HDL-C ratio, and carotid plaque: a large-scale cross-sectional study in a Chinese health check-up population

Herbal targeting of mitochondrial dynamic proteins in low-density lipoprotein driven atherosclerosis in vitro