A vitamin-biomarker risk score for 90-day functional outcome after acute ischemic stroke: development and internal validation in a retrospective cohort - Report - MDSpire
Advertisement
A vitamin-biomarker risk score for 90-day functional outcome after acute ischemic stroke: development and internal validation in a retrospective cohort
Clinical Report: Vitamin-Based Risk Score for Predicting Outcomes After Stroke
Overview
This study developed a vitamin-based nomogram to predict 90-day functional outcomes in acute ischemic stroke (AIS) patients. Internal validation demonstrated good discrimination and calibration.
Background
Acute ischemic stroke (AIS) is a leading cause of mortality and disability globally, making early risk stratification crucial for effective treatment planning. Vitamin-related biomarkers have been associated with stroke prognosis.
Data Highlights
Outcome
Good Outcome (mRS ≤ 2)
Poor Outcome (mRS 3–6)
Number of Patients
309 (47.18%)
346 (52.82%)
AUC (Training Set)
0.878
AUC (Test Set)
0.880
Key Findings
Vitamin D, E, A, K1, B12, folate, and homocysteine are independent predictors of poor outcomes after AIS.
The nomogram achieved an AUC of 0.878 in the training set and 0.880 in the test set.
The vitamin-based model outperformed the clinical baseline model (AUC 0.734) significantly (DeLong p < 0.001).
Internal validation was performed using 1,000 bootstrap resamples.
The combined model did not significantly improve over the vitamin-based model (ΔAUC = −0.005; p = 0.582).
Clinical Implications
The vitamin-based nomogram requires further external validation before routine clinical implementation.
Conclusion
The development of a vitamin-based risk score requires further validation in multicenter studies.
