Socioeconomic Factors and Their Impact on Cardiovascular-Kidney-Metabolic Syndrome at the Census Tract Level - Report - MDSpire

Socioeconomic Factors and Their Impact on Cardiovascular-Kidney-Metabolic Syndrome at the Census Tract Level

  • By

  • Vaishnavi Krishnan

  • Xiaoning Huang

  • Cyanna McGowan

  • Nilay S. Shah

  • Farah Qureshi

  • Cynthia S. Minkovitz

  • Kiarri N. Kershaw

  • Alexa A. Freedman

  • Gregory E. Miller

  • Donald M. Lloyd-Jones

  • Sadiya S. Khan

  • April 9, 2026

  • 0 min

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Clinical Report: Socioeconomic Factors and Their Impact on CKM Syndrome

Overview

This study examines the correlation between various neighborhood indices and median household income with the prevalence of cardiovascular-kidney-metabolic (CKM) conditions at the census tract level. The findings suggest that neighborhood indices may provide incremental value in understanding CKM conditions beyond median household income alone.

Background

Cardiovascular-kidney-metabolic (CKM) syndrome encompasses interrelated health conditions that significantly impact public health through increased morbidity and mortality. Understanding the influence of socioeconomic factors on CKM conditions is critical for developing effective public health strategies. Recent evidence highlights the importance of social determinants of health, particularly neighborhood characteristics, in shaping health outcomes.

Data Highlights

This study utilized publicly available census tract-level data to analyze the prevalence of CKM conditions in relation to various neighborhood indices and median household income.

Key Findings

  • Seven neighborhood indices were analyzed: ADI, COI, EJI, NDI, SDI, SREI, and SVI.
  • Median household income was compared against these indices to assess their correlation with CKM conditions.
  • Crude prevalence rates of CKM conditions were derived from the CDC's Population Level Analysis dataset.
  • Indices capturing socioeconomic deprivation explained significant geographic variability in CKM condition prevalence.
  • Direct comparisons between indices have not been extensively studied prior to this research.

Clinical Implications

Healthcare professionals should consider the broader socioeconomic context when assessing CKM conditions in patients. Utilizing neighborhood indices may enhance risk stratification and inform targeted interventions for at-risk populations.

Conclusion

The study underscores the importance of integrating neighborhood socioeconomic factors into the understanding and management of CKM syndrome, potentially guiding public health initiatives and clinical practices.

References

  1. European Journal of Preventive Cardiology, 2023 -- Cardiovascular–kidney–metabolic syndrome and mortality in a prospective UK cohort study
  2. European Journal of Preventive Cardiology, 2023 -- Socioeconomic disparities and risk of recurrent cardiovascular events and cardiovascular disease-free life expectancy in patients with established cardiovascular disease
  3. American Journal of Epidemiology, 2023 -- Addressing the Difficulties in Assessing Socioeconomic Disparities in Pharmacoepidemiology Research
  4. The Journal of Clinical Endocrinology & Metabolism, 2023 -- Association Between Metabolic Syndrome and Kidney Stone Formation: Insights from 487,860 Participants in the UK Biobank
  5. A Synopsis of the Evidence for the Science and Clinical Management of Cardiovascular-Kidney-Metabolic (CKM) Syndrome - Professional Heart Daily | American Heart Association
  6. AHA Presidential Advisory on CKM Syndrome
  7. 11. Chronic Kidney Disease and Risk Management: Standards of Care in Diabetes—2025 - PMC

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