Clinical Report: Relationship Between CTI and Microvascular Obstruction in AMI

Overview

This study evaluates the association between the C-reactive protein-triglyceride glucose index (CTI) and microvascular obstruction (MVO) in acute myocardial infarction (AMI) patients post-percutaneous coronary intervention (PCI). Higher baseline CTI levels are linked to increased MVO risk.

Background

Microvascular obstruction (MVO) is a significant complication following PCI for AMI, impacting long-term outcomes such as heart failure and adverse left ventricular remodeling. Identifying biomarkers like the CTI, which integrates systemic inflammation and insulin resistance, may assist in risk stratification in AMI patients.

Data Highlights

Key Findings

• Higher baseline CTI levels are significantly associated with increased risk of MVO (OR = 1.33).
• A linear dose-response relationship exists between CTI levels and MVO risk.
• During a median follow-up of 43 months, higher CTI levels correlate with increased long-term MACE risk.
• This association is particularly pronounced in non-diabetic patients.

Clinical Implications

CTI can be utilized as a biomarker for assessing the risk of MVO in AMI patients.

Conclusion

CTI is independently associated with MVO following PCI in AMI patients and demonstrates prognostic value for long-term MACE.

Related Resources & Content

1. Frontiers in Cardiovascular Medicine, 2026 -- Association between the C-reactive protein-triglyceride-glucose index and the presence and prognosis of coronary microvascular dysfunction in patients with chronic coronary syndrome
2. Frontiers in Medicine, 2026 -- Association between the C-reactive protein-triglyceride-glucose index and major adverse cardiovascular events in patients undergoing percutaneous coronary intervention
3. Frontiers in Cardiovascular Medicine, 2026 -- The association between the C-reactive protein-triglyceride glucose index and myocardial injury after acute ischemic stroke: a machine learning analysis of the brain-heart axis
4. 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes | JACC
5. Frontiers in Cardiovascular Medicine — Unveiling a J-shaped association between the triglyceride-glucose index and in-hospital major adverse cardiovascular events in patients with acute myocardial infarction: a retrospective cohort study of 1,065 patients
6. Prognostic impact of persistent microvascular obstruction on cardiac magnetic resonance after STEMI: A systematic review and meta-analysis
7. 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines | JACC
8. Frontiers | Association between the C-reactive protein-triglyceride-glucose index and the presence and prognosis of coronary microvascular dysfunction in patients with chronic coronary syndrome