Comparison of Care Cascade Outcome Measures for Hepatitis C Among Insured US Adults - Report - MDSpire

Comparison of Care Cascade Outcome Measures for Hepatitis C Among Insured US Adults

  • By

  • Hasan Symum

  • Brooke Hoots

  • Harvey W. Kaufman

  • William A. Meyer

  • Ademola Osinubi

  • Andrew Kress

  • William W. Thompson

  • Carolyn Wester

  • July 6, 2026

  • 0 min

Share

Clinical Report: Evaluation of Hepatitis C Care Cascade Outcomes Among Insured Adults

Overview

This cohort study evaluates hepatitis C care outcomes among insured adults in the U.S., revealing that 39.9% achieved viral clearance, while 35.7% initiated treatment.

Background

Hepatitis C virus (HCV) can lead to severe liver disease and mortality if untreated, but direct-acting antivirals (DAAs) can cure over 95% of cases.

Data Highlights

OutcomePercentage
Viral Clearance39.9%
Treatment Initiation35.7%
Viral Clearance After Treatment Initiation26.1%

Key Findings

  • Of 4,515,568 adults tested for HCV, 91,491 ever had HCV.
  • 62.0% of those with HCV had initial infection.
  • 38.3% of individuals with initial infection did not have follow-up RNA testing.
  • 73.2% of those who initiated treatment had a subsequent HCV RNA-negative result.
  • 21.3% of individuals without treatment initiation had evidence of viral clearance.

Clinical Implications

Healthcare providers should be aware of the limitations in data sources when evaluating treatment outcomes.

Conclusion

The findings highlight critical gaps in the hepatitis C care cascade.

Related Resources & Content

  1. Open Forum Infectious Diseases, 2022 -- Assessment of the Hepatitis C Virus Clearance Pathway in Individuals Coinfected with HIV and HCV Using Health Department Surveillance Data from Seven US Regions Emphasizes the Importance of Engagement in HIV Care
  2. BMC Infectious Diseases, 2022 -- Impact of the COVID-19 pandemic on hepatitis C care across the cascade of care: a scoping review
  3. Open Forum Infectious Diseases, 2022 -- Evaluation of Hepatitis C Screening Practices in the US Veterans Health Administration Following the Universal Screening Recommendations by the United States Preventive Services Task Force
  4. Clinical Screening and Diagnosis for Hepatitis C | Hepatitis C | CDC
  5. AASLD/IDSA 2023 Clinical Practice Guidance Update for Testing, Managing, and Treating Hepatitis C Virus Infection
  6. Open Forum Infectious Diseases — Progress Towards Hepatitis C Eradication in Taiwan: Perspectives from the Hemodialysis Patient Group
  7. Clinical Screening and Diagnosis for Hepatitis C | Hepatitis C | CDC
  8. AASLD/IDSA 2023 Clinical Practice Guidance Update for Testing, Managing, and Treating Hepatitis C Virus Infection
  9. Glecaprevir–Pibrentasvir for 8 or 12 Weeks in HCV Genotype 1 or 3 Infection

Original Source(s)

Related Content