Chronic Cough Despite Normal Workup - Report - MDSpire

Chronic Cough Despite Normal Workup

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  • Kathryn Wighton

  • February 13, 2026

  • 2 min

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Chronic Cough Despite Normal Workup

Overview

A case of a middle-aged woman with a chronic cough lasting 3 months, unresponsive to standard treatments, led to the diagnosis of cough-predominant laryngeal hypersensitivity syndrome. This condition is characterized by heightened laryngeal cough reflex sensitivity, often overlooked in routine evaluations.

Background

Chronic cough can significantly impact quality of life, yet many patients remain undiagnosed despite normal workups. Laryngeal hypersensitivity syndrome is a sensory disorder that complicates the diagnosis of chronic cough, necessitating targeted evaluations beyond standard imaging and pulmonary tests. Understanding this condition is crucial for effective management and improving patient outcomes.

Data Highlights

No numerical data available in the article.

Key Findings

  • The patient exhibited a chronic dry cough for 3 months with no response to inhalers or cough suppressants.
  • Standard evaluations, including imaging and pulmonary function tests, were normal.
  • Flexible bronchoscopy revealed marked laryngeal hypersensitivity, triggering cough with minimal stimulation.
  • Laryngeal hypersensitivity syndrome can complicate the diagnosis of chronic cough, often remaining unrecognized.
  • Management includes conservative strategies such as patient education, hydration, and behavioral cough suppression techniques.

Clinical Implications

Clinicians should consider laryngeal hypersensitivity syndrome in patients with unexplained chronic cough despite normal evaluations. A multidisciplinary approach, including behavioral therapies and psychosocial support, may enhance patient management and quality of life.

Conclusion

This case highlights the importance of recognizing laryngeal hypersensitivity syndrome in chronic cough patients, emphasizing the need for targeted evaluations and comprehensive management strategies.

References

  1. Muhammad Ammar Iqbal, Cureus, 2023 -- Chronic Cough Despite Normal Workup
  2. Clinical Research in Cardiology — 2023 Update on GOLD COPD Guidelines: Essential Insights for Cardiologists
  3. Infection — A Glimmer of Optimism: Recovery of Histopathological and Functional Outcomes Following Severe COVID-19
  4. European Radiology — Pulmonary Imaging Findings in Adult Patients with Primary Immunodeficiency Disorders: A Comprehensive Review
  5. Frontiers in Medicine — Case Report: Adult fibrinous bronchitis associated with lymphatic reflux: a probable diagnosis based on convergent evidence
  6. ERS guidelines on the diagnosis and treatment of chronic cough in adults and children
  7. Efficacy of behavioral cough suppression therapy for refractory chronic cough
  8. Efficacy and safety of gefapixant, a P2X3 receptor antagonist, in refractory chronic cough and unexplained chronic cough (COUGH-1 and COUGH-2): results from two double-blind, randomised, parallel-group, placebo-controlled, phase 3 trials - ScienceDirect

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