Intraoperative functional brain mapping for glioma surgery: a comprehensive review of the University of California San Francisco mapping protocol - Report - MDSpire

Intraoperative functional brain mapping for glioma surgery: a comprehensive review of the University of California San Francisco mapping protocol

  • By

  • Jia-Shu Chen

  • Brandon Bergsneider

  • Alexander F. Haddad

  • Ramin A. Morshed

  • Shawn L. Hervey-Jumper

  • Jacob S. Young

  • Mitchel S. Berger

  • June 13, 2026

  • 0 min

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Clinical Report: Intraoperative Brain Mapping Techniques for Glioma Resection

Overview

This report analyzes the UCSF protocol for intraoperative brain mapping techniques during glioma resection, emphasizing the importance of preserving neurological function while achieving maximal tumor resection. The findings highlight the effectiveness of awake and asleep mapping techniques in reducing postoperative deficits and improving patient outcomes.

Background

Maximal safe resection of gliomas is critical for improving patient survival and quality of life. Intraoperative brain mapping techniques are essential for identifying functional brain areas, thereby minimizing the risk of neurological deficits during surgery. As surgical techniques evolve, understanding the optimal implementation of these mapping protocols is increasingly important for neurosurgeons.

Data Highlights

No numerical data available in the article.

Key Findings

  • Intraoperative brain mapping is associated with fewer neurological deficits and higher rates of maximal resection.
  • Awake mapping techniques have been shown to improve late neurological outcomes compared to non-awake approaches.
  • The UCSF protocol includes awake language mapping and asleep triple modality motor mapping to enhance patient safety and comfort.
  • Functional outcomes are significantly better when mapping is utilized, particularly in eloquent cortex regions.
  • Postoperative neurological morbidity is linked to worse overall survival, underscoring the importance of preserving function during resection.

Clinical Implications

Neurosurgeons should prioritize the use of intraoperative brain mapping techniques to enhance surgical outcomes and minimize neurological deficits. Familiarity with both awake and asleep mapping protocols can improve the extent of resection while safeguarding patient function.

Conclusion

Intraoperative brain mapping is a vital component of glioma surgery, facilitating maximal resection with minimal functional compromise. Continued refinement and dissemination of mapping techniques will enhance surgical practice and patient outcomes.

Related Resources & Content

  1. Gerritsen et al., Neuro-Oncology, 2023 -- Intraoperative Brain Mapping Techniques for Glioma Resection
  2. Awake Tumor Resection Utilizing Direct Electrical Stimulation Mapping and Real-Time Cognitive Assessment: Our Approach
  3. An Innovative Neurosurgical Technique for Extensive Resection of Non-Dominant Precuneal Gliomas: A Case Study
  4. Utilizing Indirect Cognitive Mapping Techniques in Glioma Surgery for Patients Ineligible for Awake Craniotomy – My Approach
  5. Preoperative nTMS Evaluation: An Effective Method for Identifying Potential Motor Impairments in Patients with Brain Tumors
  6. Awake Tumor Resection Utilizing Direct Electrical Stimulation Mapping and Real-Time Cognitive Assessment: Our Approach
  7. An Innovative Neurosurgical Technique for Extensive Resection of Non-Dominant Precuneal Gliomas: A Case Study
  8. Utilizing Indirect Cognitive Mapping Techniques in Glioma Surgery for Patients Ineligible for Awake Craniotomy – My Approach
  9. EANS-EANO guidelines on the extent of resection in gliomas
  10. Impact of awake mapping on extent of resection and neurological outcomes of Low-grade gliomas: a systematic review and Meta-analysis - PubMed
  11. A comprehensive framework for glioma surgery by the PIONEER Consortium and RANO resect group, part 1: intraoperative recommendations for mapping, monitoring, and decision making - PubMed

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