Huangjin Shuangshen decoction alleviates chronic atrophic gastritis by suppressing TNF/NF-κB signaling and promoting CFTR-associated gastric mucosal barrier repair - Report - MDSpire

Huangjin Shuangshen decoction alleviates chronic atrophic gastritis by suppressing TNF/NF-κB signaling and promoting CFTR-associated gastric mucosal barrier repair

  • By

  • Shuo Zhang

  • Shuya Zhang

  • Mengyi Wang

  • Xueru Huang

  • Chen Huang

  • Tao Jiang

  • Guangji Zhang

  • July 10, 2026

  • 0 min

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Clinical Report: Huangjin Shuangshen Decoction Mitigates Chronic Atrophic Gastritis

Overview

Huangjin Shuangshen Decoction (HJSS) has been studied for its effects on chronic atrophic gastritis (CAG). The study investigates the impact of HJSS on inflammation and gastric mucosal barrier integrity.

Background

Chronic atrophic gastritis (CAG) is a significant precancerous condition that can progress to gastric cancer. Current treatment options are limited.

Data Highlights

OutcomeEffect of HJSS
Gastric mucosal atrophyAlleviated
Histopathological injuryImproved
Inflammatory burdenReduced
Apoptosis-associated injuryAttenuated
Recovery of CFTR, ZO-1, MUC5AC, Occludin, Claudin-1Promoted

Key Findings

  • HJSS alleviated gastric mucosal atrophy and histopathological injury in CAG.
  • Improved gastric function indices were observed following HJSS treatment.
  • HJSS reduced inflammatory mediators and apoptosis-related markers.
  • Recovery of gastric mucosal barrier-associated molecules was enhanced by HJSS.
  • HJSS suppressed TNF/NF-κB signaling and reduced p65 nuclear translocation.

Clinical Implications

Clinicians should consider the role of multi-component herbal formulas in treating chronic gastric disorders.

Conclusion

HJSS is associated with effects on chronic atrophic gastritis, including anti-inflammatory effects and enhancement of gastric mucosal barrier recovery.

Related Resources & Content

  1. Huang et al., Frontiers in Immunology, 2023 -- Huangjin Shuangshen Decoction Mitigates Chronic Atrophic Gastritis
  2. Frontiers in Immunology — Modified Huangqi Chifeng decoction alleviates IgA nephropathy inflammation and renal fibrosis via miR-146a/TLR4/NF-κB signaling modulation
  3. Frontiers in Immunology — Qijia Rougan Formula alleviates liver fibrosis by inhibiting NLRP3-mediated pyroptosis and regulating macrophage polarization
  4. Frontiers in Immunology — Tao-Hong-Si-Wu-Tang protects against methionine- and choline-deficient diet-induced hepatic steatosis in rats and is associated with inhibition of oxidative stress, inflammation, apoptosis, and pyroptosis
  5. Frontiers in Immunology — Exploring the mechanism by which modified huangqi chifeng decoction protects podocytes via Arid5a-mediated transcriptional regulation of the AIM2 pyroptosis signaling axis
  6. Management of epithelial precancerous conditions and early neoplasia of the stomach (MAPS III): ESGE, EHMSG, ESP Guideline update 2025
  7. AGA Clinical Practice Guidelines on Management of Gastric Intestinal Metaplasia
  8. Asian Pacific Association of Gastroenterology task force recommendations on surveillance for Helicobacter pylori associated gastric premalignant conditions - PMC
  9. Eradication Therapy to Prevent Gastric Cancer in Helicobacter pylori–Positive Individuals: Systematic Review and Meta-Analysis of Randomized Controlled Trials and Observational Studies - ScienceDirect
  10. Gastric cancer prevention by community eradication of Helicobacter pylori: a cluster-randomized controlled trial - PubMed
  11. Eradication of Helicobacter pylori in the Primary Prevention of Gastric Cancer: A Systematic Review and Meta-Analysis - PMC
  12. Signaling pathways and targeted interventions for precancers | Signal Transduction and Targeted Therapy
  13. Cystic fibrosis and inflammatory bowel disease: parallels in gut physiology and microbiota | Journal of Bacteriology
  14. JCI - Usage information: Epithelial TNF controls cell differentiation and CFTR activity to maintain intestinal mucin homeostasis

Original Source(s)

Huangjin Shuangshen decoction alleviates chronic atrophic gastritis by suppressing TNF/NF-κB signaling and promoting CFTR-associated gastric mucosal barrier repair

  • by Shuo Zhang, Shuya Zhang, Mengyi Wang, Xueru Huang, Chen Huang, Tao Jiang, Guangji Zhang

  • July 10, 2026

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