Systemic propranolol and topical moist wound dressings for ulcerated infantile hemangioma of the scrotum: a case report - Report - MDSpire

Systemic propranolol and topical moist wound dressings for ulcerated infantile hemangioma of the scrotum: a case report

  • By

  • Jiejun Xia

  • Kunshan Chen

  • Zhenyin Liu

  • Xiaoyun Tan

  • Shifeng Xie

  • Haibo Li

  • May 4, 2026

  • 0 min

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Management of Ulcerated Scrotal Infantile Hemangioma in an Infant

Overview

This case report presents the effective management of an ulcerated scrotal infantile hemangioma in a 5-month-old male using systemic propranolol and topical moist dressings. The combined treatment resulted in rapid healing and favorable cosmetic outcomes.

Background

Ulcerated infantile hemangiomas (UIHs) are a significant clinical challenge, particularly when located in high-risk areas such as the scrotum. These lesions can lead to complications including infection and prolonged healing times. Effective management strategies are essential to improve patient outcomes and minimize complications.

Data Highlights

The patient achieved complete epithelialization of the ulcer within 12 days of treatment, with infection controlled in 3 days. Follow-up at three months showed no significant hypertrophic scarring.

Key Findings

  • Systemic propranolol at a maintenance dose of 2 mg/kg/d was effective in managing the hemangioma.
  • Topical moist wound healing strategies, including alginate dressings and recombinant human epidermal growth factor gel, facilitated rapid healing.
  • The combined treatment approach led to complete epithelialization of the ulcer within 12 days.
  • Localized infection was controlled within 3 days of initiating treatment.
  • Three-month follow-up confirmed favorable cosmetic results with no significant hypertrophic scarring.

Clinical Implications

This case highlights the importance of a multimodal approach in treating ulcerated infantile hemangiomas, particularly in sensitive anatomical areas. Clinicians should consider combining systemic beta-blockers with tailored local wound care to optimize healing and cosmetic outcomes.

Conclusion

The successful management of this case underscores the potential benefits of integrating systemic propranolol with customized moist wound healing strategies for ulcerated infantile hemangiomas. Further studies may help to refine treatment protocols.

References

  1. American Academy of Pediatrics, Pediatrics, 2021 -- Diagnosis and Management of Infantile Hemangioma
  2. A Randomized, Controlled Trial of Oral Propranolol for Infantile Hemangioma, NEJM, 2015
  3. Clinical Features, Prognostic Factors, and Treatment Interventions for Ulceration in Patients With Infantile Hemangioma, JAMA Dermatology, 2020
  4. Drugs - Real World Outcomes — Efficacy of Propranolol in Treating Infantile Hemangioma Among Mexican Pediatric Patients
  5. Assessment of the Effectiveness of Oxygen-Enriched Oil-Based Gel Dressings in Patients Following Surgical Repair of Distal Hypospadias: A Prospective Randomized Clinical Study
  6. Hernia — Management of a Giant Inguinoscrotal Hernia with Preoperative Pneumoperitoneum: A Case Study Highlighting an Unexpected Complication and Literature Review
  7. Frontiers in Medicine — Multimodal management of late-stage Bockenheimer disease complicated by severe anemia and coagulopathy: a case report
  8. Diagnosis and Management of Infantile Hemangioma | Pediatrics | American Academy of Pediatrics
  9. A Randomized, Controlled Trial of Oral Propranolol for Infantile Hemangioma
  10. Clinical Features, Prognostic Factors, and Treatment Interventions for Ulceration in Patients With Infantile Hemangioma | Pediatrics | JAMA Dermatology | JAMA Network

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