MemSAM-2.5D: overcoming volumetric discontinuity and boundary ambiguity for 3D liver tumor segmentation - Report - MDSpire

MemSAM-2.5D: overcoming volumetric discontinuity and boundary ambiguity for 3D liver tumor segmentation

  • By

  • Yinyin Hou

  • Ningning Chen

  • Tingting Huo

  • Weijia Wang

  • July 8, 2026

  • 0 min

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Clinical Report: MemSAM-2.5D for 3D Segmentation of Liver Tumors

Overview

MemSAM-2.5D is a novel segmentation framework designed for liver tumor delineation in 3D CT scans. It addresses challenges related to volumetric discontinuities and boundary uncertainties.

Background

Accurate segmentation of liver tumors is critical for the management of hepatocellular carcinoma (HCC). Traditional methods face challenges due to variability in tumor size, discontinuities in volumetric imaging, and ambiguous tumor boundaries.

Data Highlights

MemSAM-2.5D was evaluated on multiple datasets, including MSD08, HCC-TACE-Seg, and WAW-TACE.

Key Findings

  • MemSAM-2.5D integrates a Hybrid Mamba-Adapter (HMA) for enhanced intra-slice feature representation.
  • The Z-axis State Flow (ZSF) module models long-range dependencies between slices.
  • The Confidence-Gated Prototype Memory (CGPM) module refines boundaries by evaluating predictive uncertainty.
  • Evaluations show improvements in overlap-based, boundary-sensitive, and continuity-related metrics.
  • MemSAM-2.5D provides a solution for HCC segmentation.

Clinical Implications

The MemSAM-2.5D framework offers a promising approach to improve the accuracy of liver tumor segmentation in clinical settings. Its ability to address volumetric and boundary challenges may enhance diagnostic precision and treatment planning for HCC.

Conclusion

MemSAM-2.5D represents an advancement in the segmentation of liver tumors from 3D CT volumes.

Related Resources & Content

  1. Lee et al., npj Digital Medicine, 2025 -- Multi-View Collaborative Learning for Semi-Supervised CT Segmentation of Liver Tumors in Resource-Limited Environments Using Foundation Model Guidance
  2. Pan et al., npj Digital Medicine, 2025 -- StructSAM: Adapting Prompts with Structural Awareness for Enhanced Segmentation of Lung Cancer Lesions in CT Imaging
  3. Han et al., npj Digital Medicine, 2025 -- PAM: a propagation-based model for segmenting any 3D objects across multi-modal medical images
  4. Gul et al., npj Digital Medicine, 2026 -- Enhanced Mamba Filtering Networks for Precise Segmentation of Hepatocellular Carcinoma Lesions in Abdominal CT Scans
  5. AASLD, PubMed, 2025 -- Critical Update: AASLD Practice Guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma
  6. Springer Nature, 2026 -- Efficacy and safety of immune-based combinations in metastatic hepatocellular carcinoma: a systematic review and network meta-analysis
  7. Critical Update: AASLD Practice Guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma - PubMed
  8. Efficacy and safety of immune-based combinations in metastatic hepatocellular carcinoma: a systematic review and network meta-analysis | BMC Cancer | Springer Nature Link
  9. 956607 | Stanford Health Care

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