Dysregulated lipid metabolites GML and GMO were associated with cytotoxic T cell function and serve as biomarkers for acute pulmonary embolism - Report - MDSpire
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Dysregulated lipid metabolites GML and GMO were associated with cytotoxic T cell function and serve as biomarkers for acute pulmonary embolism
Clinical Report: Altered lipid metabolites GML and GMO correlate with cytotoxic T cell activity
Overview
This study identifies glycerol monolaurate (GML) and glycerol monooleate (GMO) as serum metabolites associated with acute pulmonary embolism (APE). Elevated levels of these metabolites correlate with cytotoxic T cell dysfunction and disease severity in APE patients.
Background
Acute pulmonary embolism (APE) is a significant cause of cardiovascular mortality, often misdiagnosed due to nonspecific symptoms. The identification of reliable biomarkers is crucial for early diagnosis and risk stratification.
Data Highlights
Parameter
Findings
Upregulated Serum Lipids
203
Downregulated Serum Lipids
57
GML and GMO Levels
Significantly elevated in APE
Correlation with Cytotoxic T Cell Markers
Decreased granzyme B, perforin, granulysin
Key Findings
203 serum lipids were upregulated and 57 downregulated in APE patients compared to controls.
Serum GML and GMO levels were significantly higher in APE patients than in healthy controls and other diseases.
GML and GMO correlated with clinical risk stratification in APE.
ROC analyses indicated high sensitivity and specificity for GML and GMO as diagnostic biomarkers.
Cytotoxic T cells from APE patients showed decreased expression of granzyme B, perforin, and granulysin.
In vitro studies demonstrated that GML and GMO reduced Notch1 signaling and cytotoxic protein expression in T cells.
Clinical Implications
The findings indicate that GML and GMO may serve as biomarkers for diagnosing APE and assessing disease severity.
Conclusion
Elevated serum levels of GML and GMO may be valuable for the diagnosis of APE.
