Hemodynamic evaluation following ductal closure and association with IVH in premature infants born at 22–23weeks gestation - Report - MDSpire

Hemodynamic evaluation following ductal closure and association with IVH in premature infants born at 22–23weeks gestation

  • By

  • Tomonori Kurimoto

  • Katsuaki Toyoshima

  • Hiroshi Ohashi

  • Jun Shibasaki

  • Tomoyuki Shimokaze

  • Tomoko Saito

  • Kaoru Katsumata

  • Asataro Yara

  • Eiji Hirakawa

  • Takuya Tokuhisa

  • June 12, 2026

  • 0 min

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Clinical Report: Assessment of Hemodynamic Changes Post-Ductal Closure

Overview

This study investigates the hemodynamic changes following ductal closure in extremely preterm infants and their association with intraventricular hemorrhage (IVH).

Background

Intraventricular hemorrhage is a significant complication in extremely preterm infants, particularly those born at 22-23 weeks of gestation. The immediate post-closure period represents a critical window for monitoring.

Data Highlights

ParameterInfants with IVHInfants without IVH
End-systolic wall stressIncreasedStable
Mean arterial pressureIncreasedStable
Heart rateIncreasedStable
Mean velocity of circumferential fiber shorteningDecreasedStable

Key Findings

  • Seven out of 26 infants developed grade 2–4 IVH after ductal closure.
  • Infants with IVH exhibited significant hemodynamic changes within 12 hours post-closure.
  • Increased end-systolic wall stress, mean arterial pressure, and heart rate were observed in infants with IVH.
  • Mean velocity of circumferential fiber shortening decreased in infants who developed IVH.
  • Significant differences in hemodynamic parameters were noted at 6 and 12 hours post-closure (p < 0.01).

Clinical Implications

Monitoring hemodynamic parameters in the first 12 hours after ductal closure is essential for identifying infants at risk for IVH. Targeted interventions may be necessary during this critical period to mitigate the risk of hemorrhagic complications.

Conclusion

The study identifies hemodynamic changes following ductal closure in extremely preterm infants.

Related Resources & Content

  1. Isayama et al., JAMA Pediatrics, 2025 -- Outcomes of Preterm Infants Born at 22 to 23 Weeks’ Gestation in 11 International Neonatal Networks
  2. American Academy of Pediatrics, Pediatrics, 2025 -- Patent Ductus Arteriosus in Preterm Infants
  3. Frontiers in Pediatrics, 2026 -- Predicting severe intraventricular hemorrhage in very preterm and/or very low birth weight infants: a nomogram approach
  4. Frontiers in Pediatrics, 2026 -- Hemodynamic evaluation following ductal closure and association with IVH in premature infants born at 22-23 weeks gestation
  5. Pediatric Cardiology — Assessment of Diastolic Function in Both Ventricles of Preterm Infants During the Initial Week After Birth
  6. Pediatric Cardiology — Comparative Analysis of Longitudinal Strain and Standard Echocardiographic Metrics in Healthy Term Newborns During the Initial Week of Life
  7. Pediatric Cardiology — Comparative Outcomes of Initial versus Subsequent Ligation of Patent Ductus Arteriosus Following Pharmacological Treatment Failure in Very-Low-Birth-Weight Neonates
  8. Outcomes of Preterm Infants Born at 22 to 23 Weeks’ Gestation in 11 International Neonatal Networks | Neonatology | JAMA Pediatrics | JAMA Network
  9. Patent Ductus Arteriosus in Preterm Infants | Pediatrics | American Academy of Pediatrics
  10. Frontiers | Hemodynamic evaluation following ductal closure and association with IVH in premature infants born at 22-23weeks gestation

Original Source(s)

Hemodynamic evaluation following ductal closure and association with IVH in premature infants born at 22–23weeks gestation

  • by Tomonori Kurimoto, Katsuaki Toyoshima, Hiroshi Ohashi, Jun Shibasaki, Tomoyuki Shimokaze, Tomoko Saito, Kaoru Katsumata, Asataro Yara, Eiji Hirakawa, Takuya Tokuhisa

  • June 12, 2026

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