Demographics, Social Determinants, and Treatment Trends in Head and Neck Cancer Patients in Central Missouri - Report - MDSpire

Demographics, Social Determinants, and Treatment Trends in Head and Neck Cancer Patients in Central Missouri

  • By

  • Carson Gates

  • Elsie Barry

  • Laura Dooley

  • Stephanie Knollhoff

  • February 11, 2026

  • 0 min

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Demographics, Social Determinants, and Treatment Trends in Head and Neck Cancer Patients in Central Missouri

Overview

This study analyzes the impact of social determinants of health on head and neck cancer (HNC) patients in central Missouri. Key findings indicate that greater travel distance and higher socioeconomic deprivation are associated with advanced-stage disease at diagnosis.

Background

Head and neck cancer (HNC) presents significant challenges, particularly in rural areas where access to care is limited. Understanding the role of social determinants of health (SDOH) is crucial for improving patient outcomes and addressing disparities in cancer care. This study focuses on the demographics and treatment trends of HNC patients in central Missouri, highlighting the importance of SDOH in cancer diagnosis and management.

Data Highlights

FactorStage IV Presentation (%)p-value
Distance >100 miles530.005
Boone County Residents28

Key Findings

  • Patients living more than 100 miles from the cancer center had a 53% rate of stage IV presentation.
  • Boone County residents had a 28% rate of stage IV presentation.
  • Higher Area Deprivation Index (ADI) scores were significantly associated with advanced-stage disease (p = 0.017).
  • Travel distance (OR = 1.24) and ADI (OR = 1.06) were independently associated with higher stage at diagnosis.
  • RUCA classification and sex were not significantly associated with stage at diagnosis.

Clinical Implications

Healthcare providers should consider the impact of travel distance and socioeconomic factors when diagnosing and treating head and neck cancer patients. Addressing these social determinants may improve early detection and treatment outcomes in rural and disadvantaged populations.

Conclusion

The findings emphasize the need for targeted interventions to mitigate the effects of social determinants on head and neck cancer outcomes. Improving access to care for rural patients is essential for enhancing early diagnosis and treatment success.

Related Resources & Content

  1. Author(s)/Org, Source, Year -- Title
  2. Author(s)/Org, Source, Year -- Title
  3. The ASCO Post, 2014 -- Studies Address Impact of Social Factors on Cancer Treatment Disparities
  4. The ASCO Post, 2023 -- Head and Neck Cancers 2022–2023 Almanac GUEST EDITORS
  5. NCCN Guidelines® Insights - Head and Neck Cancers, Version 2.2025 | NCCN Continuing Education
  6. PubMed, 2023 -- Pembrolizumab with or without chemotherapy in recurrent or metastatic head and neck squamous cell carcinoma: 5-year follow-up from the randomized phase III KEYNOTE-048 study
  7. JAMA Network, 2023 -- Rurality, Health Care Resource Use, and Care Trajectories in Patients With Head and Neck Cancer
  8. NCCN Guidelines® Insights - Head and Neck Cancers, Version 2.2025 | NCCN Continuing Education
  9. Pembrolizumab with or without chemotherapy in recurrent or metastatic head and neck squamous cell carcinoma: 5-year follow-up from the randomized phase III KEYNOTE-048 study - PubMed
  10. Rurality, Health Care Resource Use, and Care Trajectories in Patients With Head and Neck Cancer | Oncology | JAMA Network Open | JAMA Network

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