Effects of ketogenic diet therapy in outpatient anti epileptic drug cost reduction and parental satisfaction among children with intractable epilepsy - Report - MDSpire

Impact of Ketogenic Diet Therapy on Reducing Outpatient Anti-Epileptic Medication Costs and Enhancing Parental Satisfaction in Children with Drug-Resistant Epilepsy

  • By

  • Achmad Rafli

  • Setyo Handryastuti

  • Amanda Soebadi

  • Dara Ninggar Santoso

  • Indira Rahmawati

  • Ryan Pramana

  • Rahadian Ramadhan

  • Clifford Peter Anthony

  • Irawan Mangunatmadja

  • July 17, 2026

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Clinical Report: Impact of Ketogenic Diet Therapy on Anti-Epileptic Costs

Overview

This study evaluates the financial impact of ketogenic diet therapy (KDT) on outpatient anti-epileptic medication costs in children with drug-resistant epilepsy (DRE). Results indicate a significant cost reduction of 21.8% after 6 months of KDT.

Background

Epilepsy is a prevalent neurological disorder affecting millions of children globally, with a significant subset experiencing drug-resistant epilepsy (DRE). Traditional anti-epileptic drugs often fail in these cases, necessitating alternative therapies like ketogenic diet therapy (KDT). Understanding the cost implications of KDT is crucial for healthcare providers and families managing DRE.

Data Highlights

MeasureCost ReductionStatistical Significance
Overall Cost Reduction21.8%p = < 0.001

Key Findings

  • KDT resulted in a 21.8% reduction in outpatient anti-epileptic drug costs.
  • The average cost reduction was Rp 3,757,812 (approximately 235 US$).
  • The study involved 16 patients aged 5–18 years with DRE.
  • Cost evaluations were conducted at 3-month intervals over 6 months.

Clinical Implications

The findings suggest that KDT may provide significant cost savings for families managing DRE in children. Additionally, the assessment of parental satisfaction highlights the importance of considering family perspectives in treatment planning.

Conclusion

Incorporating ketogenic diet therapy in the management of drug-resistant epilepsy can lead to substantial financial savings.

Related Resources & Content

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  8. American Epilepsy Society Clinical Practice Guideline: Infantile Epilepsy - PMC
  9. Frontiers | Impact of a high-fat, low-carbohydrate ketogenic diet on seizure frequency in children with drug-resistant epilepsy: a systematic review and Meta-analysis
  10. Ketogenic diet therapy enables antiseizure medication reduction and withdrawal in children with epilepsy - ScienceDirect

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