Clinical Report: Efficacy and Safety of PreserFlo MicroShunt vs Trabeculectomy

Overview

This systematic review and meta-analysis evaluates the efficacy and safety of the PreserFlo MicroShunt compared to trabeculectomy in glaucoma management. The findings indicate that while both procedures are effective in reducing intraocular pressure, they differ in safety profiles and postoperative complications.

Background

Glaucoma is a major cause of irreversible blindness, making effective management critical. Trabeculectomy is the standard surgical intervention for lowering intraocular pressure but carries risks of complications. The emergence of minimally invasive glaucoma surgeries, such as the PreserFlo MicroShunt, offers potential benefits in terms of safety and recovery, warranting comparative analysis.

Data Highlights

No specific numerical data was provided in the source material.

Key Findings

• PreserFlo MicroShunt provides a less invasive option compared to trabeculectomy.
• Both procedures effectively lower intraocular pressure, but trabeculectomy achieves lower mean IOP.
• Trabeculectomy has a higher incidence of hypotony-related complications compared to MicroShunt.
• Long-term safety profiles are favorable for both procedures, but with different risk profiles.
• MicroShunt may result in fewer revisions related to hypotony.

Clinical Implications

Clinicians should consider the trade-offs between the PreserFlo MicroShunt and trabeculectomy when recommending surgical options for glaucoma patients. The choice may depend on individual patient risk factors and the desired target intraocular pressure.

Conclusion

The PreserFlo MicroShunt represents a promising alternative to trabeculectomy, particularly for patients at higher risk of complications. Further studies are needed to refine patient selection and optimize outcomes.

Related Resources & Content

1. Efficacy and safety of PreserFlo MicroShunt versus trabeculectomy in glaucoma patients: a systematic review, meta-analysis, and meta-regression of clinical outcomes and key covariates | BMC Ophthalmology | Springer Nature Link, 2026 -- Efficacy and safety of PreserFlo MicroShunt versus trabeculectomy
2. Glaucoma Physician — Study Compares Microshunt to Trabeculectomy, 2024 -- Study Compares Microshunt to Trabeculectomy
3. Glaucoma Physician — Trabeculectomy vs Santen Microshunt in Large Study, 2020 -- Trabeculectomy vs Santen Microshunt in Large Study
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5. Glaucoma: diagnosis and management, NICE, 2025 -- Glaucoma: diagnosis and management
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8. Ab-Externo MicroShunt vs. Trabeculectomy in Primary Open-Angle Glaucoma: 5-Year Safety Results from a Randomized, Multicenter Study - ScienceDirect
9. Efficacy and safety of PreserFlo MicroShunt versus trabeculectomy in glaucoma patients: a systematic review, meta-analysis, and meta-regression of clinical outcomes and key covariates | BMC Ophthalmology | Springer Nature Link