Clinical Report: Calcium Signaling in Psoriasis: Insights into Pathogenesis

Overview

This review highlights the role of calcium signaling in psoriasis pathogenesis, emphasizing its dual regulatory functions in keratinocytes and immune cells. It discusses the dysregulation of calcium signaling and its contribution to the disease's inflammatory processes.

Background

Psoriasis is a chronic inflammatory skin disease characterized by an imbalance in keratinocyte proliferation and differentiation, alongside immune dysregulation. The IL-23/IL-17 inflammatory axis is central to its pathogenesis, driving both epidermal and immune responses. Understanding the role of calcium signaling in this context is crucial.

Data Highlights

No numerical data or trial data provided in the source material.

Key Findings

• Calcium signaling is critical for keratinocyte differentiation and immune cell activation in psoriasis.
• Dysregulation of calcium signaling contributes to impaired keratinocyte differentiation and skin barrier function.
• Persistent calcium-dependent signaling in immune cells promotes Th17 polarization and IL-17A release.
• Compartment-specific calcium dysregulation may characterize psoriasis pathology.

Clinical Implications

Understanding calcium signaling's role in psoriasis may inform future research directions.

Conclusion

This review reappraises psoriasis pathogenesis through the lens of calcium signaling.

Related Resources & Content

1. Frontiers | Calcium signaling in psoriasis: from pathogenesis to therapeutic opportunities
2. conexiant — UVB and Psoriasis: More Than Immunosuppression
3. Frontiers in Immunology — Psoriasis as a systemic inflammatory disease: an immune set-point framework for comorbidities and relapse
4. Clinical Rheumatology — The Role of Osteoimmunology in Rheumatoid and Psoriatic Arthritis: Investigating Tofacitinib's Impact on Bone Health
5. conexiant — Psoriasis–AD Switching May Mimic Treatment Failure
6. UVB and Psoriasis: More Than Immunosuppression
7. Psoriasis as a systemic inflammatory disease: an immune set-point framework for comorbidities and relapse
8. The Role of Osteoimmunology in Rheumatoid and Psoriatic Arthritis: Investigating Tofacitinib's Impact on Bone Health
9. https://register.awmf.org/assets/guidelines/013-001m_S3_Therapie-Psoriasis-vulgaris_2025-08.pdf
10. Risankizumab versus Deucravacitinib in Adults With Moderate Plaque Psoriasis: 16-Week Results from the Phase 4 IMMpactful Trial | Dermatology and Therapy | Springer Nature Link
11. Frontiers | Calcium signaling in psoriasis: from pathogenesis to therapeutic opportunities