Correlation of Peripheral Blood Levels of LUBAC and OTULIN with Acute Ischemic Stroke Severity and Prognosis

Overview

This study identifies peripheral blood levels of LUBAC and OTULIN as potential biomarkers associated with stroke severity and functional outcomes in acute ischemic stroke (AIS) patients. Specifically, higher levels of HOIP correlate with increased stroke severity and poorer outcomes, while OTULIN shows a negative association with severity.

Background

Acute ischemic stroke (AIS) is a leading cause of mortality and long-term disability, with significant global health implications. Identifying biomarkers that can predict stroke severity and outcomes is crucial for improving patient management and therapeutic strategies. The inflammatory response plays a key role in the pathophysiology of AIS, making peripheral blood markers of interest for assessing disease severity and prognosis.

Data Highlights

Key Findings

• Peripheral blood levels of HOIP and OTULIN were significantly higher in AIS patients compared to healthy controls (P < 0.001).
• HOIP was positively associated with stroke severity (β = 1.928, P < 0.001) and poor functional outcomes (OR = 5.360, P = 0.013).
• OTULIN showed a negative association with stroke severity (β = -1.060, P < 0.001), but not with poor outcomes (P = 0.119).
• There was a significant interaction between HOIP and OTULIN regarding stroke severity.
• Adding HOIP to clinical models improved the predictive accuracy for poor outcomes (AUC increased from 0.846 to 0.907).

Clinical Implications

The findings suggest that measuring peripheral blood levels of HOIP and OTULIN could enhance the assessment of stroke severity and prognosis in AIS patients. Clinicians may consider these biomarkers in conjunction with traditional clinical assessments to better stratify patient risk and tailor management strategies.

Conclusion

Peripheral blood levels of HOIP and OTULIN may serve as valuable biomarkers for assessing stroke severity and predicting functional outcomes in AIS patients. Further research is warranted to validate these findings and explore their clinical applications.

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