Psychological inflexibility and resilience in anxiety: insights from machine-learning and robust mediation-based models - Report - MDSpire

Psychological inflexibility and resilience in anxiety: insights from machine-learning and robust mediation-based models

  • By

  • Ana Ferreira Mostardinha

  • Daniela Sousa

  • Hugo Senra

  • Marco Simões

  • Ana Pina Rodrigues

  • Paula Vagos

  • Miguel Castelo-Branco

  • May 18, 2026

  • 0 min

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Clinical Report: The Relationship Between Psychological Inflexibility and Resilience in Anxiety

Overview

This study investigates the interrelationship between psychological inflexibility (PI) and resilience in relation to anxiety symptoms. Findings indicate that PI is a significant predictor of anxiety-related symptoms, with resilience dimensions mediating these associations.

Background

Anxiety disorders are among the most prevalent mental health issues globally, often leading to significant impairment in daily functioning. Understanding the factors that contribute to anxiety, such as psychological inflexibility and resilience, is crucial for developing effective interventions. Resilience is recognized as a protective factor against anxiety, highlighting the importance of addressing both PI and resilience in therapeutic settings.

Data Highlights

Variableβp-value
PI - GAD0.28≤ 0.001
PI - Anxiety0.07≤ 0.001
PI - Stress0.20≤ 0.001
PI - Stress (R-PS)0.080.004
PI - Anxiety (R-PF)0.030.03
PI - GAD (R-PS & R-PF)0.080.001

Key Findings

  • Psychological inflexibility (PI) is positively associated with anxiety, stress, and Generalized Anxiety Disorder (GAD) symptoms.
  • Resilience dimensions, particularly perception of self (R-PS) and planned future (R-PF), are significant mediators in the relationship between PI and anxiety symptoms.
  • Machine learning techniques, specifically Random Forest analysis, identified PI and resilience as key predictors of anxiety-related symptoms.
  • The study sample consisted of 313 adults, predominantly female (72.20%), with an average age of 39.29 years.
  • Interventions targeting both PI and resilience may improve coping strategies for individuals with anxiety-related symptoms.

Clinical Implications

Clinicians should consider the role of psychological inflexibility and resilience when assessing and treating patients with anxiety disorders. Interventions that enhance resilience while addressing PI may lead to better mental health outcomes and coping strategies for patients.

Conclusion

The findings underscore the interconnectedness of psychological inflexibility and resilience in relation to anxiety symptoms. Targeting these constructs in therapeutic interventions may enhance treatment efficacy for anxiety disorders.

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