Research progress on debridement, antibiotics, and implant retention (DAIR) for the treatment of periprosthetic joint infection after artificial joint replacement - Report - MDSpire
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Advancements in Debridement, Antibiotic Therapy, and Implant Preservation (DAIR) for Managing Periprosthetic Joint Infections Following Joint Replacement Surgery

  • By

  • Wenguang Feng

  • Zhichao Zhang

  • Ribusurong Pu

  • Haibin Wang

  • Rui Liu

  • Yanhong Sun

  • Guoliang Zhang

  • July 3, 2026

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Clinical Report: Advancements in DAIR for Managing Periprosthetic Joint Infections

Background

Periprosthetic joint infection (PJI) is a serious complication following total hip and knee arthroplasty, affecting 1% to 2% of patients. The DAIR procedure has emerged as a preferred treatment for acute postoperative and hematogenous PJIs due to its minimally invasive nature. Understanding the factors influencing DAIR outcomes is essential for optimizing patient care.

Data Highlights

No specific numerical data provided in the source material.

Key Findings

  • DAIR is most effective when performed within 90 days post-surgery.
  • Delays beyond one month significantly reduce the success rate of DAIR.
  • Patient-related factors, such as obesity and diabetes, impact the risk of PJI.
  • Preoperative optimization of systemic conditions is crucial for improving DAIR outcomes.
  • International guidelines recommend DAIR for acute PJI with symptom duration of less than 4 weeks and stable implants.

Clinical Implications

Timely diagnosis and intervention are critical for the success of DAIR in treating PJI.

Conclusion

DAIR remains a strategy for managing PJI, with its effectiveness largely dependent on timely intervention.

Related Resources & Content

  1. Ottesen et al., Archives of Orthopaedic and Trauma Surgery, 2026 -- Timing and microbiological profile influence long-term outcomes after debridement, antibiotics, and implant retention (DAIR) in acute hip periprosthetic joint infection
  2. Archives of Orthopaedic and Trauma Surgery, 2025 -- Chronic infections of knee megaprostheses: are “Off-Label” DAIR-Plus or partial two-stage exchange viable options?
  3. Archives of Orthopaedic and Trauma Surgery, 2026 -- Early post-operative CRP is a better predictor of DAIR failure than pre-operative CRP in total knee PJI
  4. JBJI, 2025 -- Debridement, antimicrobial therapy, and implant retention (DAIR) as curative strategy for acute periprosthetic hip and knee infections: a position paper of the European Bone & Joint Infection Society (EBJIS)
  5. Archives of Orthopaedic and Trauma Surgery — Comparative effectiveness of antimicrobial implant surface coatings in preventing orthopaedic implant-associated infections: a network meta-analysis
  6. Debridement, antimicrobial therapy, and implant retention (DAIR) as curative surgical strategy for acute periprosthetic hip and knee infections: a summary of the position paper from the European Bone & Joint Infection Society (EBJIS)
  7. JBJI - Debridement, antimicrobial therapy, and implant retention (DAIR) as curative strategy for acute periprosthetic hip and knee infections: a position paper of the European Bone & Joint Infection Society (EBJIS)
  8. Efficacy of Debridement, Antibiotics, and Implant Retention in Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis - ScienceDirect

Original Source(s)

Research progress on debridement, antibiotics, and implant retention (DAIR) for the treatment of periprosthetic joint infection after artificial joint replacement

  • by Wenguang Feng, Zhichao Zhang, Ribusurong Pu, Haibin Wang, Rui Liu, Yanhong Sun, Guoliang Zhang

  • July 3, 2026

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