Analysis of the trajectory of depressive symptoms and influencing factors in patients undergoing metabolic and bariatric surgery - Report - MDSpire

Analysis of the trajectory of depressive symptoms and influencing factors in patients undergoing metabolic and bariatric surgery

  • By

  • Jia-li Zhang

  • Yi Zhu

  • Yan Shao

  • Jing Wang

  • Cheng-yan Pu

  • Xiao-yi Yang

  • Ya-jing Xu

  • Yi Shen

  • June 10, 2026

  • 0 min

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Clinical Report: Progression of Depressive Symptoms in Obese Patients Post-MBS

Overview

This study investigates the factors influencing depressive symptoms in obese patients undergoing metabolic and bariatric surgery (MBS). It identifies key risk and protective factors affecting depression trajectories, highlighting the importance of postoperative follow-up for effective emotional management.

Background

Obesity is a significant public health issue linked to various health complications, including mental health disorders such as depression and anxiety. Metabolic and bariatric surgery (MBS) is a common intervention for severe obesity, but it can also impact patients' emotional well-being. Understanding the dynamics of depressive symptoms in this population is crucial for improving postoperative care and outcomes.

Data Highlights

Time PointDepressive Score Change
1 Month PostopSignificant Decrease
3 Months PostopSignificant Decrease
6 Months PostopSignificant Decrease

Key Findings

  • Anxiety is a consistent risk factor for developing depression post-MBS.
  • Higher medication adherence, vitality, and role emotional scores are protective against depression progression.
  • Two distinct depression trajectory subgroups were identified: mild depression decline and significant depression decline.
  • Patients with comorbid hypertension and low health transition scores had lower preoperative depression levels.
  • Patients with comorbid anxiety, low medication adherence, and high vitamin B12 levels exhibited higher preoperative depression severity.

Clinical Implications

Healthcare providers should prioritize mental health assessments and interventions for patients undergoing MBS, particularly those with anxiety disorders. Postoperative follow-up is essential for monitoring and managing depressive symptoms to enhance overall treatment outcomes.

Conclusion

The study underscores the need for targeted emotional support in obese patients post-MBS, particularly for those with anxiety and other risk factors. Continuous monitoring and tailored interventions can significantly improve patient outcomes.

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