Risk Factors for the Development of Food Allergy in Infants and Children: A Systematic Review and - Report - MDSpire

Risk Factors for the Development of Food Allergy in Infants and Children: A Systematic Review and

  • By

  • Nazmul Islam

  • Alexandro W. L. Chu

  • Falana Sheriff

  • Farid Foroutan

  • Gordon H. Guyatt

  • Romina Brignardello-Petersen

  • Paul Oykhman

  • Alfonso Iorio

  • Ariel Izcovich

  • Katherine M. Morrison

  • Yetiani Roldan Benitez

  • Rachel J. Couban

  • Dorota Borovsky

  • Yiming Zhang

  • Leonardo Ologundudu

  • Keerthana Pasumarthi

  • Syed Fahad Farooq

  • Kyle Tong

  • Wang-Choi Tang

  • Haseeb Faisal

  • Muhammad Faran Khalid

  • Mohammad Saad Asif

  • Shannon French

  • Susan Waserman

  • R. Sharon Chinthrajah

  • Hugh A. Sampson

  • S. Shahzad Mustafa

  • Jay A. Lieberman

  • Kirsi M. Järvinen

  • Sally Bailey

  • Philippe Bégin

  • Scott H. Sicherer

  • Jennifer Gerdts

  • Melanie Carver

  • Lynda Mitchell

  • Kelly Cleary

  • Matthew J. Greenhawt

  • Julie Wang

  • Aikaterini Anagnostou

  • Marcus S. Shaker

  • Anita Chandra-Puri

  • Patricia C. Fulkerson

  • Robert A. Wood

  • Derek K. Chu

  • May 1, 2026

  • 0 min

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Clinical Report: Identifying Risk Factors for Food Allergy Development in Infants and Children

Overview

This comprehensive review identifies key risk factors associated with the development of IgE-mediated food allergies in infants and children. The findings underscore the importance of early intervention and targeted prevention strategies to mitigate the rising incidence of food allergies.

Background

Food allergies represent a significant and growing global health concern, affecting over 33 million individuals in the US alone. IgE-mediated food allergies typically manifest early in life and can lead to severe, life-threatening reactions. Understanding the risk factors for food allergy development is crucial for clinicians and policymakers to implement effective prevention strategies.

Data Highlights

No specific numerical data provided in the article.

Key Findings

  • The incidence of IgE-mediated food allergy is approximately 5% by age 6 years.
  • Key risk factors include early allergic disease, delayed allergen introduction, and genetic susceptibility.
  • Antibiotic exposure during infancy is associated with increased risk of food allergies.
  • Demographic factors and birth-related variables also play a significant role in food allergy development.
  • Systematic reviews emphasize the need for evidence-based guidelines for early allergenic food introduction.

Clinical Implications

Clinicians should be aware of the multifactorial nature of food allergy risk and consider these factors when advising parents on dietary practices for infants. Early introduction of allergenic foods, particularly in high-risk populations, may help reduce the incidence of food allergies.

Conclusion

This review highlights the urgent need for systematic approaches to identify at-risk populations and implement preventive strategies against food allergies in early childhood.

References

  1. JAMA Pediatrics, 2025 -- Risk Factors for the Development of Food Allergy in Infants and Children: A Systematic Review and Meta-Analysis
  2. conexiant — Major Food Allergy Risks Clarified
  3. The New Gastroenterologist — Type of Formula Could Increase NEC Risk in Preterm Infants
  4. conexiant — IVF Babies and Allergy Risk: New Data
  5. Archives of Toxicology — Associations Between Perfluorooctanoic Acid Levels and Vaccine Response in 101 Healthy One-Year-Old Children Exposed to Perfluoroalkyl Substances (PFASs)
  6. Major Food Allergy Risks Clarified
  7. Type of Formula Could Increase NEC Risk in Preterm Infants
  8. IVF Babies and Allergy Risk: New Data
  9. Risk Factors for the Development of Food Allergy in Infants and Children: A Systematic Review and Meta-Analysis | Allergy and Clinical Immunology | JAMA Pediatrics | JAMA Network
  10. Guidelines for Early Food Introduction and Patterns of Food Allergy - PMC
  11. Introducing peanut in infancy prevents peanut allergy into adolescence | National Institutes of Health (NIH)

Original Source(s)

Risk Factors for the Development of Food Allergy in Infants and Children: A Systematic Review and

  • by Nazmul Islam, Alexandro W. L. Chu, Falana Sheriff, Farid Foroutan, Gordon H. Guyatt, Romina Brignardello-Petersen, Paul Oykhman, Alfonso Iorio, Ariel Izcovich, Katherine M. Morrison, Yetiani Roldan Benitez, Rachel J. Couban, Dorota Borovsky, Yiming Zhang, Leonardo Ologundudu, Keerthana Pasumarthi, Syed Fahad Farooq, Kyle Tong, Wang-Choi Tang, Haseeb Faisal, Muhammad Faran Khalid, Mohammad Saad Asif, Shannon French, Susan Waserman, R. Sharon Chinthrajah, Hugh A. Sampson, S. Shahzad Mustafa, Jay A. Lieberman, Kirsi M. Järvinen, Sally Bailey, Philippe Bégin, Scott H. Sicherer, Jennifer Gerdts, Melanie Carver, Lynda Mitchell, Kelly Cleary, Matthew J. Greenhawt, Julie Wang, Aikaterini Anagnostou, Marcus S. Shaker, Anita Chandra-Puri, Patricia C. Fulkerson, Robert A. Wood, Derek K. Chu

  • May 1, 2026

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