Clinical Report: Analysis of Thirty-Three Cases of Heterotopic Pregnancy Following Assisted Reproductive Techniques

Overview

This study analyzed 33 cases of heterotopic pregnancy to assess factors influencing intrauterine pregnancy outcomes. Key findings include that 66.67% of patients achieved viable ongoing intrauterine gestation or live birth.

Background

Heterotopic pregnancy is a rare condition characterized by the presence of both intrauterine and ectopic gestational sacs. Its incidence has increased with advancements in assisted reproductive technologies.

Data Highlights

Key Findings

• 66.67% of patients achieved viable ongoing intrauterine gestation or live birth.
• Sequential identification of an intrauterine gestational sac, embryo, and fetal cardiac activity was associated with higher odds of successful intrauterine pregnancy (P < 0.001).
• Fetal cardiac activity had the strongest predictive value for sustained pregnancy (OR = 22.00, P < 0.001).
• No significant differences in outcomes were observed between blastocyst and cleavage-stage embryo transfers.
• Better intrauterine embryonic development correlated with higher odds of favorable pregnancy outcomes (OR = 28.75, P = 0.003).

Clinical Implications

Ultrasound markers indicating intrauterine development were observed in this study.

Conclusion

The study presents findings on ultrasound assessment in heterotopic pregnancy.

Related Resources & Content

1. Frontiers in Medicine, 2026 -- New insights gained from a decade long multi-center retrospective study on the management strategy for heterotopic pregnancy: expectant management is worth considering in patients without vaginal bleeding
2. Frontiers in Medicine, 2026 -- Clinical pregnancy after ICSI: an exploratory transfer-day analysis of female age, AMH, sperm source, and transfer stage
3. conexiant -- 31 Live Births Reported Following Uterus Transplant
4. NICE, 2026 -- Diagnosis of viable intrauterine pregnancy and of tubal ectopic pregnancy | Ectopic pregnancy and miscarriage: diagnosis and initial management | Guidance
5. ESHRE -- Ectopic pregnancy
6. The Journal of Clinical Endocrinology & Metabolism — Outcomes of Perinatal and Maternal Health Following Transfer of Blastocysts from Nonpronuclear and Monopronuclear Embryos
7. Laparoscopy versus laparotomy for the treatment of heterotopic pregnancy: a systematic review and meta-analysis
8. Diagnosis of viable intrauterine pregnancy and of tubal ectopic pregnancy | Ectopic pregnancy and miscarriage: diagnosis and initial management | Guidance | NICE
9. Ectopic pregnancy
10. Prise en charge thérapeutique des grossesses extra-utérines tubaires : recommandations pour la pratique clinique du Collège national des gynécologues et obstétriciens français et de la Société de chirurgie gynécologique et pelvienne - ScienceDirect
11. L26/P-900 Outcomes of uterine heterotopic pregnancies after in vitro fertilisation–embryo transfer | Human Reproduction | Oxford Academic
12. Intrauterine pregnancy outcomes after laparoscopic heterotopic pregnancy management: a retrospective study of identifying risk factors and prognostic indicators | BMC Pregnancy and Childbirth | Springer Nature Link
13. Full article: The association between endometrial thickness and ectopic pregnancy among women who underwent in vitro fertilization, systematic review and meta-analysis
14. Management of tubal ectopic pregnancy | Ectopic pregnancy and miscarriage: diagnosis and initial management | Guidance | NICE