Clinical Report: Bioactive Adrenomedullin as a Biomarker for Severe Infections

Overview

This exploratory study investigates bioactive adrenomedullin (bio-ADM) as a potential biomarker for predicting bacteremia in emergency department patients with suspected severe infections. The findings suggest that bio-ADM levels correlate with sepsis severity and may enhance early diagnosis and management in emergency settings.

Background

Incorporate statistics on the effectiveness of current clinical scores and their limitations.

Data Highlights

This study utilized a prospective cohort design to assess the predictive value of bio-ADM in emergency department patients with suspected severe infections.

Key Findings

• Bio-ADM levels were significantly higher in patients with septic shock and non-survivors.
• Bio-ADM was found to be an independent predictor of mortality and organ failure in ICU patients with sepsis.
• In the emergency department, elevated bio-ADM levels correlated with increased odds of mortality and multi-organ failure.
• Bio-ADM demonstrated better predictive capability for 28-day mortality compared to CRP, lactate, or creatinine.
• Point-of-care testing for bio-ADM may facilitate rapid diagnosis and management of sepsis in emergency settings.

Clinical Implications

The use of bio-ADM as a biomarker in emergency departments could enhance the early identification of patients at risk for severe infections and sepsis. Implementing bio-ADM testing may improve patient triage and management, potentially reducing morbidity and mortality associated with delayed treatment.

Conclusion

Highlight specific areas for future research to validate bio-ADM's clinical utility.

References

1. Mebazaa A, et al., Infection, 2025 -- Evaluating the Prognostic Significance of Circulating Bioactive Adrenomedullin in Sepsis Outcomes and Hydrocortisone Efficacy: Insights from the HYPRESS Trial Post-Hoc Analysis
2. SCCM, Surviving Sepsis Campaign Adult Guidelines -- Current guidance on sepsis diagnosis and management
3. Clinical Research in Cardiology — Utilizing the Adrenomedullin System to Tailor Diuretic Therapy After Discharge in Acute Heart Failure Patients
4. Infection — Evaluating the Diagnostic Accuracy of Monocyte Distribution Width (MDW) for Identifying Infection and Sepsis in Emergency Department Patients on a Sepsis Pathway
5. Infection — Pro-atrial natriuretic peptide (pro-ANP) concentrations in individuals with severe sepsis and septic shock: implications for diagnosis and prognosis
6. PubMed - Clinical value of circulating bioactive adrenomedullin for prediction of outcome and hydrocortisone response in sepsis patients
7. Surviving Sepsis Campaign Adult Guidelines | SCCM