Analysis of ultrasonic characteristics in 12 cases of ovarian Sertoli–Leydig cell tumour - Report - MDSpire

Analysis of ultrasonic characteristics in 12 cases of ovarian Sertoli–Leydig cell tumour

  • By

  • Liyang Shao

  • Weihong Dong

  • Shuang Li

  • Qiongrui Zhao

  • Tingting Liu

  • Kaikai Li

  • Tian Wu

  • Yu Wang

  • Haohui Zhu

  • Ruili Wang

  • June 23, 2026

  • 0 min

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Ultrasonic Imaging Features in Twelve Cases of Ovarian Sertoli–Leydig Cell Tumors

Background

Sertoli–Leydig cell tumors (SLCTs) are a rare type of ovarian neoplasm, accounting for approximately 0.5% of all ovarian tumors. These tumors often present with hyperandrogenic symptoms. Ultrasound serves as the primary imaging modality for evaluating adnexal masses, yet distinguishing SLCTs from other ovarian neoplasms can be challenging.

Data Highlights

CharacteristicFindings
Histological Classification5 well-differentiated, 5 moderately differentiated, 1 moderately to poorly differentiated, 1 retiform
Mass Type7 solid, 3 cystic-solid, 2 cystic
Internal Vascularity4 in 1, 3 in 7, 2 in 2, 1 in 2
Peripheral Vascularity4 in 8, 1 in 2, 0 in 2
Surrounding Ball PatternObserved in 8 instances (66.7%)
Elevated Testosterone LevelsAll 9 patients tested showed elevated levels

Key Findings

  • 41.7% of tumors were well-differentiated, and 41.7% were moderately differentiated.
  • 58.3% of tumors were categorized as solid, while 25.0% were cystic-solid.
  • 66.7% of cases exhibited a surrounding ball vascular pattern.
  • All patients with preoperative testosterone levels showed elevated values.
  • Ultrasound findings should be considered descriptive observations rather than definitive diagnostic criteria.

Clinical Implications

The distinctive ultrasound features of SLCTs, including solid or cystic-solid masses with peripheral vascularity, may aid in the early suspicion and diagnosis of this tumor type.

Conclusion

The study highlights the importance of recognizing specific ultrasound features of ovarian SLCTs to enhance diagnostic accuracy.

Related Resources & Content

  1. European Radiology, 2024 -- Key Insights on MRI and CT for the Evaluation and Staging of Adnexal Masses: Recommendations from ESUR
  2. Current Strategies and Future Directions, 2021 -- Illustrating the Challenges in Imaging Testicular Cancer Through Three Case Studies
  3. Diagnostic Imaging Techniques for Evaluating Renal Tumors and Assessing Treatment Response, 2018
  4. European Radiology, 2025 -- Enhancing O-RADS MRI: Expanding Beyond Cancer Risk Assessment
  5. Ultrasound in Obstetrics & Gynecology, 2026 -- Terms, definitions and measurements to describe the sonographic features of adnexal tumors: updated consensus opinion from the International Ovarian Tumor Analysis (IOTA) Group
  6. NCCN Clinical Practice Guidelines in Oncology, 2026
  7. Frontiers in Oncology, 2026 -- Analysis of Ultrasonic Characteristics in 12 Cases of Ovarian Sertoli–Leydig Cell Tumour
  8. Journal of Clinical Ultrasound, 2026 -- Clinical and Ultrasound Features of Ovarian Sertoli–Leydig Cell Tumors: A Case Series and Literature Review
  9. Terms, definitions and measurements to describe the sonographic features of adnexal tumors: updated consensus opinion from the International Ovarian Tumor Analysis (IOTA) Group
  10. NCCN Clinical Practice Guidelines in Oncology
  11. Frontiers | Analysis of Ultrasonic Characteristics in 12 Cases of Ovarian Sertoli–Leydig Cell Tumour
  12. Clinical and Ultrasound Features of Ovarian Sertoli–Leydig Cell Tumors: A Case Series and Literature Review - Wang - Journal of Clinical Ultrasound - Wiley Online Library
  13. Contrast-enhanced ultrasound findings of ovarian Sertoli-Leydig cell tumor: a case report with ultrasonographic-pathological insights - PubMed
  14. Survival outcomes and treatment patterns in malignant ovarian sex cord-stromal tumors: A population-based analysis - ScienceDirect
  15. Ovarian Sex Cord-Stromal Neoplasms: An Overview of Molecular Events and How to Correlate Morphology With Molecular Findings - PubMed

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