Case report : Early-Onset Juvenile Psoriatic Arthritis Presenting at 15 Months: A Diagnostic Challenge in Infancy - Report - MDSpire

Case report : Early-Onset Juvenile Psoriatic Arthritis Presenting at 15 Months: A Diagnostic Challenge in Infancy

  • By

  • Atawneh, Mayar

  • Hasasna, Lana

  • Atyani, Moath

  • Alami, Mohammad

  • Abunejma, Fawzy M.

  • April 29, 2026

  • 0 min

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Clinical Report: Diagnosing Early-Onset Juvenile Psoriatic Arthritis in a 15-Month-Old

Overview

This case study presents a rare instance of juvenile psoriatic arthritis (JPsA) in a 15-month-old, characterized by guttate psoriatic lesions followed by knee arthritis. The diagnosis was confirmed through ultrasound and adherence to ILAR criteria.

Background

Juvenile psoriatic arthritis is a significant pediatric rheumatic condition that can lead to long-term joint damage if not diagnosed and treated promptly. Early recognition is crucial, especially in atypical cases.

Data Highlights

No numerical data or trial data available in the source material.

Key Findings

  • A 15-month-old female presented with guttate psoriatic lesions followed by knee arthritis.
  • Diagnosis of JPsA was confirmed using the ILAR criteria despite negative autoimmune serology.
  • Ultrasound imaging was utilized to confirm synovitis in the affected knee.
  • Positive family history for autoimmune diseases was noted.
  • Timely initiation of disease-modifying therapy led to sustained clinical remission.

Clinical Implications

Clinicians should consider juvenile psoriatic arthritis in young patients presenting with guttate psoriasis and joint symptoms, even in the absence of positive autoimmune markers. Early imaging and adherence to diagnostic criteria are essential for effective management.

Conclusion

This case highlights the recognition of early-onset juvenile psoriatic arthritis in infants.

Related Resources & Content

  1. Frontiers in Immunology, 2026 -- Clinical Characteristics, Autoantibody Profiles, and Therapeutic Outcomes of Juvenile Systemic Sclerosis: An 11-Year Single-Center Experience from China
  2. Frontiers in Pediatrics, 2026 -- Childhood-onset systemic lupus erythematosus presenting with growth retardation and delayed puberty: a case report
  3. Clinical Rheumatology, 2025 -- Assessment of ILAR and PRINTO Criteria for Juvenile Idiopathic Arthritis: Comparing Oligoarticular JIA with Early-Onset ANA-Positive JIA
  4. European Radiology, 2025 -- Key Insights on Juvenile Idiopathic Arthritis for Radiologists: Recommendations from the European Society of Paediatric Radiology
  5. Pediatric Rheumatology, 2021 -- Juvenile Psoriatic Arthritis (JPsA): juvenile arthritis with psoriasis?
  6. American College of Rheumatology, 2026 -- ACR Releases Updated Juvenile Idiopathic Arthritis Guidelines
  7. PMC, 2022 -- Secukinumab in enthesitis-related arthritis and juvenile psoriatic arthritis: a randomised, double-blind, placebo-controlled, treatment withdrawal, phase 3 trial
  8. Juvenile Psoriatic Arthritis (JPsA): juvenile arthritis with psoriasis? | Pediatric Rheumatology | Full Text
  9. ACR Releases Updated Juvenile Idiopathic Arthritis Guidelines | American College of Rheumatology
  10. Secukinumab in enthesitis-related arthritis and juvenile psoriatic arthritis: a randomised, double-blind, placebo-controlled, treatment withdrawal, phase 3 trial - PMC

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