The Relationship Between Glycated Hemoglobin Levels and In-Stent Restenosis After Percutaneous Coronary Intervention in Patients with Coronary Artery Disease - Report - MDSpire
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The Relationship Between Glycated Hemoglobin Levels and In-Stent Restenosis After Percutaneous Coronary Intervention in Patients with Coronary Artery Disease
Clinical Report: Glycated Hemoglobin Levels and In-Stent Restenosis After PCI
Overview
This study investigates the relationship between glycated hemoglobin (HbA1c) levels and the risk of in-stent restenosis (ISR) in patients with coronary artery disease (CAD) following percutaneous coronary intervention (PCI). Higher HbA1c levels were found to be significantly associated with an increased risk of ISR, particularly in patients with HbA1c levels ≥6.5%.
Background
Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide, with in-stent restenosis (ISR) representing a significant complication following PCI. Understanding the factors contributing to ISR is crucial for improving patient outcomes and optimizing treatment strategies. Glycated hemoglobin (HbA1c) serves as an important biomarker for glycemic control, and its relationship with ISR risk has not been fully elucidated in CAD patients.
Data Highlights
HbA1c Category
Number of Patients
Proportion
HbA1c <5.7%
914
14.51%
HbA1c ≥5.7% to <6.5%
2783
44.20%
HbA1c ≥6.5%
2600
41.29%
Key Findings
1305 individuals (20.72%) were diagnosed with ISR among 6297 CAD patients post-PCI.
Higher HbA1c levels were significantly linked to increased ISR risk, with an odds ratio (OR) of 1.18 (95% CI 1.09–1.27, p <0.0001).
Patients with HbA1c ≥6.5% had a substantially higher ISR risk (OR: 1.70, 95% CI 1.26–2.29, p =0.0005).
A non-linear association was observed between HbA1c levels and ISR risk, with a threshold effect at HbA1c 7.8%.
Below the threshold of 7.8%, the association between HbA1c and ISR risk was more pronounced.
Clinical Implications
Clinicians should monitor HbA1c levels in CAD patients undergoing PCI, as higher levels are associated with an increased risk of ISR. Early identification and management of elevated HbA1c may help mitigate ISR risk and improve patient outcomes following PCI.
Conclusion
This study highlights the significant association between elevated HbA1c levels and the risk of ISR in CAD patients after PCI, emphasizing the need for effective glycemic control in this population.
