Inflammatory biomarkers and 30-day thoracic outcomes after surgical versus non-surgical management of spontaneous pneumothorax: a retrospective cohort study - Report - MDSpire
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Inflammatory biomarkers and 30-day thoracic outcomes after surgical versus non-surgical management of spontaneous pneumothorax: a retrospective cohort study
Clinical Report: Association of Inflammatory Biomarkers with 30-Day Thoracic Outcomes
Overview
This study evaluates the association of inflammatory biomarkers with 30-day thoracic outcomes following surgical and non-surgical treatment of spontaneous pneumothorax.
Background
Spontaneous pneumothorax (SP) can lead to significant morbidity, and understanding the impact of treatment strategies on outcomes is crucial. The role of inflammatory biomarkers in predicting recovery and complications post-treatment remains an area of active investigation. This study aims to clarify the relationship between these biomarkers and short-term outcomes in patients undergoing different management approaches for SP.
Data Highlights
Outcome
VATS
Non-Surgical
p-value
30-day thoracic complications
13.2%
28.5%
< 0.001
Hospital stay (median days)
5.00
3.00
< 0.001
Antibiotic use
26.2%
7.7%
< 0.001
Key Findings
VATS was associated with higher post-treatment inflammatory indices (SII, PLR, NLR, WBC).
VATS resulted in fewer 30-day post-discharge thoracic complications (13.2% vs. 28.5%, p < 0.001).
Patients undergoing VATS had a longer median hospital stay (5.00 days vs. 3.00 days, p < 0.001).
Antibiotic use was more frequent in the VATS group (26.2% vs. 7.7%, p < 0.001).
In weighted models, surgery was associated with a lower risk of complications (OR = 0.38, p = 0.002).
Elevated inflammatory biomarkers post-surgery may indicate surgical stress rather than infection.
Clinical Implications
The findings suggest that while VATS may reduce the risk of complications, it also leads to longer hospital stays and increased antibiotic use. Clinicians should consider these factors when discussing treatment options with patients.
Conclusion
VATS is associated with improved short-term outcomes in terms of complications but requires careful consideration of the increased hospitalization and antibiotic use.
