Clinical Report: Analyzing the Research Landscape of Neutrophil Extracellular Traps

Overview

This bibliometric study analyzes the growth and development of research on neutrophil extracellular traps (NETs) in pulmonary diseases from 2006 to 2025. It highlights the significant increase in publications, particularly post-2019, and identifies key contributors and evolving research themes.

Background

Neutrophil extracellular traps (NETs) play a dual role in pulmonary diseases, contributing to both pathogen elimination and potential tissue damage. Understanding the research landscape surrounding NETs is crucial, as pulmonary diseases are a leading cause of global morbidity and mortality. This study provides insights into the trends and focal points of research in this area, which is essential for guiding future investigations.

Data Highlights

Key Findings

• 1,539 articles from 561 journals were analyzed.
• Research on NETs in pulmonary diseases has seen phased growth, particularly after 2019.
• China and the United States are the leading contributors to this research domain.
• Mark R. Looney is identified as a core author in this field.
• Key research themes have shifted from fundamental mechanisms to topics like COVID-19 and biomarkers.

Clinical Implications

The findings indicate a growing interest in the role of NETs in various pulmonary diseases, which may inform future therapeutic strategies. Understanding the dual nature of NETs could lead to better management of conditions like COVID-19 and interstitial lung disease.

Conclusion

This bibliometric analysis reveals significant trends in NET research related to pulmonary diseases, highlighting the need for further exploration of their therapeutic potential.

Related Resources & Content

1. Frontiers in Immunology, 2026 -- Neutrophil extracellular traps and pyroptosis: a molecular nexus linking systemic autoimmune diseases to atherosclerosis
2. Frontiers in Immunology, 2026 -- A feedback loop sustaining neutrophil extracellular trap formation involves S100 proteins, histones, TLR2 and RAGE, and is restrained by albumin
3. Open Forum Infectious Diseases, 2021 -- Investigating Gene Expression Markers Linked to Neutrophil Extracellular Traps for Assessing Mortality Risk in Neonatal Sepsis
4. Frontiers in Immunology, 2026 -- Research landscape, thematic evolution, and translational insights of immune checkpoint inhibitor-induced colitis: a bibliometric analysis (2006-2025)
5. Cystic Fibrosis Foundation, 2025 -- Chronic Medications to Maintain Lung Health Clinical Care Guidelines
6. European Respiratory Society, 2025 -- Clinical practice guideline for the management of adult bronchiectasis
7. Chronic Medications to Maintain Lung Health Clinical Care Guidelines | Cystic Fibrosis Foundation
8. European Respiratory Society clinical practice guideline for the management of adult bronchiectasis | European Respiratory Society
9. https://www.nature.com/articles/s41598-025-20832-x.pdf