Clinical efficacy and safety of subtotal resection of adenomyotic lesions based on the Kishi classification: a retrospective case series study - Report - MDSpire

Clinical efficacy and safety of subtotal resection of adenomyotic lesions based on the Kishi classification: a retrospective case series study

  • By

  • Zhenyue Qin

  • Dan Song

  • Zhiyong Dong

  • Bingying Lu

  • Weiwei Wei

  • Jiming Chen

  • June 11, 2026

  • 0 min

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Clinical Report: Efficacy and Safety of Subtotal Resection for Adenomyosis

Overview

This study evaluates the efficacy and safety of subtotal resection of adenomyotic lesions based on the Kishi classification in patients desiring uterine preservation. Significant improvements were observed in dysmenorrhea, menstrual blood loss, hemoglobin levels, and CA125 levels post-treatment.

Background

Adenomyosis is a prevalent condition characterized by the presence of endometrial tissue within the myometrium, often leading to debilitating symptoms. Current treatment options lack standardization, particularly for patients wishing to preserve their uterus while managing severe symptoms. The Kishi classification offers a framework for tailoring treatment strategies based on lesion characteristics.

Data Highlights

Clinical ParameterPreoperative ValuePostoperative ValueP-Value
Dysmenorrhea Severity ScoreHighSignificantly Reduced< 0.001
Menstrual Blood Loss ScoreHighSignificantly Reduced< 0.001
Hemoglobin ConcentrationLowSignificantly Increased< 0.001
CA125 LevelElevatedSignificantly Reduced< 0.001
Uterine VolumeIncreasedSignificantly Reduced< 0.001

Key Findings

Specify the nature of the mild complications related to the intrauterine device.

Clinical Implications

Discuss the rationale behind the combination therapy and its potential benefits.

Conclusion

Subtotal resection based on the Kishi classification appears to be an effective and safe treatment for severe adenomyosis in patients desiring uterine preservation. Further prospective studies are needed to validate these findings.

Related Resources & Content

  1. Guideline No. 437: Diagnosis and Management of Adenomyosis - ScienceDirect
  2. Guideline No. 437: Diagnosis and Management of Adenomyosis - PubMed
  3. Risk of Recurrence and Reintervention After Uterine-Sparing Interventions for Symptomatic Adenomyosis: A Systematic Review and Meta-Analysis - PMC
  4. Challenges in Assessing Submucosal Invasion Depth in T1 Colorectal Carcinomas
  5. Outcomes of Kono-S Anastomosis in Patients with Terminal Ileum Crohn's Disease: A Cohort Analysis
  6. Endoscopic Removal of Colorectal Circumferential and Near-Circumferential Laterally Spreading Lesions: Efficacy and Stenosis Risk Assessment
  7. Results of Endoscopic Resection for Large Colorectal Lesions Following Previous Incomplete Resection or Significant Manipulation
  8. Guideline No. 437: Diagnosis and Management of Adenomyosis - ScienceDirect
  9. Guideline No. 437: Diagnosis and Management of Adenomyosis - PubMed
  10. Risk of Recurrence and Reintervention After Uterine-Sparing Interventions for Symptomatic Adenomyosis: A Systematic Review and Meta-Analysis - PMC

Original Source(s)

Clinical efficacy and safety of subtotal resection of adenomyotic lesions based on the Kishi classification: a retrospective case series study

  • by Zhenyue Qin, Dan Song, Zhiyong Dong, Bingying Lu, Weiwei Wei, Jiming Chen

  • June 11, 2026

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