Longitudinal Changes in Adiposity after a Youth Sport-Related Knee Injury: Informing Post-Traumatic Osteoarthritis Prevention - Report - MDSpire
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Changes in Body Fat Over Time Following Knee Injuries in Young Athletes: Insights for Preventing Post-Traumatic Osteoarthritis

  • By

  • Justin M. Losciale

  • Nuria EJ Jansen

  • Christina Y. Le

  • Leo Lu

  • Hui Xie

  • Marienke van Middelkoop

  • Jackie L. Whittaker

  • July 13, 2026

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Clinical Report: Changes in Body Fat Over Time Following Knee Injuries

Overview

This study investigates the changes in body fat among young athletes following sport-related knee injuries compared to uninjured peers. Findings indicate no significant differences in fat mass gain between the two groups over a 24-month period.

Background

Knee injuries in youth athletes are associated with an increased risk of developing overweight or obesity, which can further elevate the risk for post-traumatic osteoarthritis (PTOA). Understanding the patterns of adiposity change following these injuries is crucial for developing effective prevention strategies.

Data Highlights

Time PointFat Mass Change (kg)95% Confidence Interval
Baseline--
6 months0.9-0.2 to 2.0
12 months0.7-0.4 to 1.9
18 months-0.1-1.4 to 1.1
24 months-0.9-2.3 to 0.6

Key Findings

  • No significant differences in fat mass gain between injured and uninjured youth over 24 months.
  • Fat mass changes were minimal at all follow-up time points.
  • Injured youth had similar adiposity gains compared to uninjured peers.
  • Findings suggest a potential window for obesity prevention in the post-injury period.
  • Results did not vary significantly between different types of knee injuries or by sex.

Clinical Implications

The findings indicate that clinicians should monitor body composition in young athletes post-knee injury, as similar adiposity gains may occur regardless of injury status.

Conclusion

The study highlights that adiposity changes in youth following knee injuries do not differ significantly from uninjured peers.

Related Resources & Content

  1. Losciale J.M., Wahlen G.E., et al., Arthritis Care & Research, 2023 -- Changes in Body Fat Over Time Following Knee Injuries in Young Athletes
  2. Frontiers in Medicine — Association of MRI-derived muscle-fat composition with knee osteoarthritis severity: a gender-stratified X-ray and MRI correlation study
  3. Frontiers in Immunology — From mechanical triggering to metabolic-inflammatory driving: a new paradigm of knee osteoarthritis pathogenesis
  4. Weight Loss Achieved by Patients Following Primary Total Knee Arthroplasty Comparable to That of a Matched General Population
  5. Clinical Rheumatology — Six-session non-operative exercise program yields sustained benefits for up to 18 months in end-stage knee osteoarthritis: a retrospective cohort study
  6. Association of MRI-derived muscle-fat composition with knee osteoarthritis severity
  7. From mechanical triggering to metabolic-inflammatory driving: a new paradigm of knee osteoarthritis pathogenesis
  8. Preventing Osteoarthritis After an Anterior Cruciate Ligament Injury: An Osteoarthritis Action Alliance Consensus Statement
  9. Female, woman and/or girl Athlete Injury pRevention (FAIR) practical recommendations: International Olympic Committee (IOC) consensus meeting held in Lausanne, Switzerland, 2025 | British Journal of Sports Medicine
  10. Follow up to the 2018 IOC consensus statement on paediatric ACL injuries: towards a broader vision of care
  11. APKASS 2024 consensus statement on anterior cruciate ligament reconstruction, Part I: Management of paediatric anterior cruciate ligament injury - ScienceDirect
  12. The Adolescent Athlete and the Team Physician: A Consensus Statement. 2025 Update - PubMed
  13. "American Academy of Orthopaedic Surgeons Appropriate Use Criteria: Cas" by Richard Ma, Kendall Hamilton et al.
  14. Risk factors for the development of knee osteoarthritis across the lifespan: A systematic review and meta-analysis - PubMed
  15. Does metabolically healthy obesity increase the risk of knee and hand osteoarthritis? A population-based cohort study | BMC Musculoskeletal Disorders | Springer Nature Link
  16. The impact of exercise therapy on rehabilitation outcomes after anterior cruciate ligament reconstruction: a network meta-analysis | BMC Musculoskeletal Disorders | Springer Nature Link
  17. Associations of sport and exercise participation in adolescence with body composition and device-measured physical activity in adulthood: longitudinal data from the Norwegian HUNT study - PubMed
  18. A roadmap for developing a program to self-manage post-traumatic knee osteoarthritis risk - ScienceDirect
  19. Preventing osteoarthritis after anterior cruciate ligament injury: The case for targeting pre-osteoarthritis illness - Osteoarthritis and Cartilage
  20. Preferences for Posttraumatic Osteoarthritis Prevention Strategies in Individuals With Anterior Cruciate Ligament Injury - Kennedy - 2026 - Arthritis Care & Research - Wiley Online Library

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