How Does That Large Language Model Make You Feel? - Report - MDSpire

How Does That Large Language Model Make You Feel?

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  • Simon Spichak

  • June 30, 2026

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Clinical Report: What Emotions Are Evoked by Large Language Models?

Overview

The use of large language models (LLMs) for mental health support is growing, despite limited data on their safety and effectiveness. Experts emphasize the need for more research.

Background

The integration of large language models into mental health support raises important questions about their efficacy and safety. As many individuals turn to these AI tools for assistance, it is crucial to evaluate their impact on mental health outcomes.

Data Highlights

In a survey of over 1800 US adults, 35% reported using AI tools for mental health support more than once a week, including those already seeing a human provider.

Key Findings

  • Many individuals are using LLMs for mental health support, often alongside traditional therapy.
  • Experts call for more research to assess the safety and effectiveness of LLMs in mental health contexts.
  • General-purpose LLMs may not be designed for crisis management.
  • Some companies are developing clinically validated chatbots, but comparisons with general-purpose LLMs are lacking.
  • Simulation studies may not accurately reflect real-world interactions with chatbots.

Clinical Implications

Clinicians should be aware of the increasing use of LLMs among patients. Ongoing research is necessary to understand the safety and effectiveness of these tools.

Conclusion

As the use of LLMs in mental health support continues to rise, further research is needed to ensure their safe application in clinical settings.

Related Resources & Content

  1. Spichak S, Resolvve, 2025 -- What Emotions Are Evoked by Large Language Models?
  2. DIGITAL HEALTH — Factors shaping the adoption of large language models among hospital administrative staff: A cross-sectional survey study
  3. npj Digital Medicine — The evaluation illusion of large language models in medicine
  4. Journal of Medical Internet Research (JMIR) — Performance of Vision-Enabled Large Language Models in Image-Based Electrocardiogram Interpretation: Exploratory Evaluation
  5. npj Digital Medicine — Evaluating the performance of general purpose large language models in identifying human facial emotions
  6. Factors shaping the adoption of large language models among hospital administrative staff: A cross-sectional survey study
  7. The evaluation illusion of large language models in medicine
  8. Systematic review and meta analysis of chatbots in the management of depressive and anxiety symptoms
  9. Marketing Submission Recommendations for a Predetermined Change Control Plan for Artificial Intelligence-Enabled Device Software Functions | FDA
  10. Psychiatry.org - Survey of APA Members Reveals Optimism, Concern About Use of AI in Practice

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