Clinical Report: Insights into Diagnosis and Management of Penile Melanoma
Background
Penile melanoma is a rare and aggressive form of mucosal melanoma, accounting for less than 2% of penile tumors and less than 0.1% of all melanomas. Its low incidence is associated with high mortality rates and late diagnosis. Currently, no dedicated clinical guidelines exist for its management.
Data Highlights
No numerical data or trial data presented in the article.
Key Findings
Three cases of primary penile melanoma were surgically treated and pathologically diagnosed.
Postoperative genetic testing and chemotherapy in one case led to a marked reduction of lymph node metastasis.
Two patients died from disease progression, while one died from other causes.
The literature review included 27 additional reported cases, indicating typical manifestations of pigmented patches or nodules on the glans or foreskin.
Surgical treatment remains the primary option, with adjuvant therapies like chemotherapy and radiotherapy commonly used.
Emerging treatments such as immune checkpoint inhibitors and targeted therapies are being evaluated in clinical trials.
Clinical Implications
A personalized management strategy is crucial for penile melanoma, focusing on complete surgical resection.
Conclusion
Penile melanoma is a rare malignancy that requires a comprehensive approach to management.
