Risk stratification and real-world management of pediatric AAORCA: discordance between anatomical features and clinical symptoms - Report - MDSpire

Risk stratification and real-world management of pediatric AAORCA: discordance between anatomical features and clinical symptoms

  • By

  • Jinjin Yu

  • Shushui Wang

  • Qinchang Chen

  • Ping Zhu

  • Wei Pan

  • July 15, 2026

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Clinical Report: Evaluating Risk Factors and Clinical Management of Pediatric AAORCA

Overview

This study investigates the anatomical predictors of clinical symptoms in pediatric patients with anomalous aortic origin of the right coronary artery (AAORCA) and evaluates management patterns. It highlights the discordance between anatomical features and clinical presentation.

Background

Anomalous aortic origin of a coronary artery (AAOCA) is a rare congenital anomaly that can lead to serious cardiovascular events. The prevalence of AAORCA in the pediatric population is increasing due to enhanced imaging techniques, yet the clinical presentation remains highly variable.

Data Highlights

CharacteristicValue
Number of patients151
Mean age7.40 ± 4.87 years
Percentage male60.9%
Percentage symptomatic51.7%

Key Findings

  • 51.7% of patients presented with symptoms.
  • Patient age was independently associated with symptom presentation.
  • Ostial stenosis had a stronger unadjusted association with symptoms than other anatomical features.
  • No anatomical variable remained independently associated with symptoms after multivariable adjustment.
  • Substantial heterogeneity in management strategies was observed among patients with high-risk anatomical findings.

Clinical Implications

Clinicians should consider a comprehensive evaluation of both clinical presentation and anatomical characteristics in managing pediatric AAORCA patients.

Conclusion

Pediatric AAORCA presents significant variability in clinical presentation and management strategies.

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