Realizing the value of the divergence event in clinical human-AI interaction - Report - MDSpire
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Recognizing the Significance of Divergence in Clinical Human–AI Interactions

  • By

  • Florence X. Doo

  • Gabriel A. Brat

  • Sarah C. Rossetti

  • Robert Klitzman

  • Charles E. Binkley

  • October 13, 2026

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Clinical Report: Recognizing the Significance of Divergence in Clinical Human–AI Interactions

Overview

The article argues that differences between clinician and AI outputs should be treated as human–AI divergence, not simply as disagreement or an error to correct. It proposes making these events visible and documenting the interaction, including the distinct information available to each party and how clinicians engage with AI reasoning.

Background

Clinical AI interfaces commonly present an output for clinicians to accept, override, or modify, leaving the interaction behind that decision largely undocumented. Clinicians remain responsible for recommendations and explanations to patients, while navigating autonomy, accountability, and liability. The source notes that clinicians may lack practical means to act as a human in the loop, and that explainability has not consistently improved decisions and can foster false confidence in erroneous outputs. A cited review of AI ethics in nursing and midwifery also reports concern that efficiency-focused AI may make relational dimensions of care less visible.

Data Highlights

The supplied article excerpt contains no numerical trial results. It describes three dimensions of human–AI divergence visibility: structural (workflow and interface), informational (what each party knows), and behavioral (clinician engagement with AI reasoning).

Key Findings

  • The article defines a divergence event as a difference between clinician and AI outputs and uses “divergence” rather than “disagreement” because the parties may have access to different information.
  • Clinicians contribute bedside assessment, communication with families, and, during procedures, haptic, visual, and anatomical-variant information that AI systems may not readily access or integrate.
  • AI systems process structured or semi-structured health-record data and may draw on patterns from large numbers of prior cases or external databases.
  • Divergence may arise from asymmetric information, genuine differences in interpreting shared evidence, or an error by either party; seeking another opinion may not address divergence caused by information asymmetry.
  • The article identifies possible clinician responses including evaluating which assessment is correct, combining signals, uncritically accepting AI output (automation bias), or reflexively overriding it (automation neglect).
  • Related work describes a collaborative human–AI engagement framework, BRACE, that centers the clinician–AI interaction rather than model output; the supplied abstract does not provide outcome data.

Clinical Implications

The article proposes documenting the interaction itself, including what the clinician and AI each contributed when their outputs diverged, rather than recording only the final decision. It also emphasizes that clinicians must determine what to recommend and explain to patients while considering autonomy, accountability, and liability.

Conclusion

Human–AI divergence is presented as a high-signal point for examining how clinical and AI reasoning differ, not merely as a contest over which output is correct. The article calls for visibility into the interaction so that its contributions and sources of divergence can be examined.

Related Resources & Content

  1. Journal of Medical Internet Research, 2026 — Backcasting the Trust Gap: A Strategic Road Map for Clinician Adoption of AI Diagnostics by 2040
  2. Frontiers in Digital Health, 2026 — Reevaluating Artificial Intelligence in Clinical Decision-Making: A Model for Collaborative Human-AI Engagement
  3. STAT News, 2026 — Using AI in addiction medicine could be particularly risky
  4. American Medical Association, 2026 — AMA policies to ensure AI supports—not replaces—physician judgment
  5. American College of Radiology, 2026 — ACR Approves First Practice Parameter for Imaging Artificial Intelligence
  6. The Royal College of Radiologists, 2026 — Guidance published: Post deployment monitoring of AI medical imaging devices
  7. European Commission — AI Act: Shaping Europe’s digital future
  8. Critical Care (Springer) — Beyond models: a paradigm shift toward human-centered AI system design
  9. AMA policies to ensure AI supports—not replaces—physician judgment
  10. ACR Approves First Practice Parameter for Imaging Artificial Intelligence
  11. Guidance published: Post deployment monitoring of AI medical imaging devices
  12. AI Act | Shaping Europe’s digital future
  13. From tool to teammate in a randomized controlled trial of clinician-AI collaborative workflows for diagnosis | npj Digital Medicine
  14. An LLM chatbot to facilitate primary-to-specialist care transitions: a randomized controlled trial | Nature Medicine
  15. Human–large language model collaboration in clinical medicine: a systematic review and meta-analysis | npj Digital Medicine
  16. Subversion of clinical judgment by conversational artificial intelligence | medRxiv
  17. Clinician in the loop: a flawed solution for AI oversight | The BMJ
  18. A governance framework for agentic AI assuming clinical functions | American Medical Association

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