Serum uric acid-to-HDL cholesterol ratio and stroke prevalence: NHANES 1999–2018 with external support from an imaging-confirmed hemorrhagic stroke dataset - Report - MDSpire

Serum uric acid-to-HDL cholesterol ratio and stroke prevalence: NHANES 1999–2018 with external support from an imaging-confirmed hemorrhagic stroke dataset

  • By

  • Tiansheng Su

  • Yong Mo

  • Guangxiang Huang

  • Jiachao Lu

  • Shuling Tang

  • Qin Hu

  • Qianrong Huang

  • Fangzhou Guo

  • Ligen Mo

  • Jun Yan

  • June 26, 2026

  • 0 min

Share

Association Between Uric Acid to HDL Cholesterol Ratio and Stroke Incidence

Overview

This study investigates the relationship between the uric acid to HDL cholesterol ratio (UHR) and stroke prevalence using NHANES data from 1999 to 2018.

Background

Stroke is a leading cause of death and disability globally, with significant healthcare costs. Uric acid has emerged as a potential biomarker linked to metabolic and inflammatory processes that may influence cerebrovascular health.

Data Highlights

MeasureValue
Odds Ratio for UHR and Stroke1.02 (1.01–1.03)
Increased Stroke Prevalence in Top UHR Quartile1.37 (1.17–1.61)
AUC for Stroke Discrimination0.825

Key Findings

  • Higher UHR levels are associated with increased odds of prevalent stroke.
  • Individuals in the top UHR quartile have a 37% higher prevalence of stroke compared to those in the lowest quartile.
  • The relationship between UHR and stroke prevalence is approximately linear.
  • Diabetes status modifies the association, with stronger links observed in non-diabetic individuals.
  • Findings were consistent in a separate cohort with imaging-confirmed hemorrhagic stroke.

Clinical Implications

Further research is warranted to explore the potential role of UHR in risk assessment.

Conclusion

The study supports the investigation of UHR as a marker for cerebrovascular risk.

Related Resources & Content

  1. Author(s)/Org, Source, Year -- Title
  2. American Heart Association, 2024 Primary Prevention of Stroke Guideline
  3. Hyperuricemia and the risk of stroke incidence and mortality: A systematic review and meta-analysis - PMC
  4. Frontiers in Neurology — Association between uric acid to lymphocyte ratio and poor functional outcomes in acute ischemic stroke patients
  5. American Journal of Epidemiology — Exploring the Inverse Relationship Between LDL-C Levels and Hemorrhagic Stroke Risk in Hypertensive Chinese Adults: Insights from the Chinese Multi-provincial Cohort Study
  6. The Journal of Clinical Endocrinology & Metabolism — Link Between Serum 25-Hydroxyvitamin D Levels and Stroke Risk: An Observational Mediation and Mendelian Randomization Analysis
  7. European Radiology — Impact of Plaque Features on Long-Term Stroke Recurrence in Individuals with Intracranial Atherosclerotic Disease: A Cohort Study Utilizing 3D High-Resolution MRI
  8. 2024 Primary Prevention of Stroke Guideline - Professional Heart Daily | American Heart Association
  9. Hyperuricemia and the risk of stroke incidence and mortality: A systematic review and meta-analysis - PMC
  10. Increased uric acid to high-density lipoprotein ratio positively correlated with stroke risk

Original Source(s)

Serum uric acid-to-HDL cholesterol ratio and stroke prevalence: NHANES 1999–2018 with external support from an imaging-confirmed hemorrhagic stroke dataset

  • by Tiansheng Su, Yong Mo, Guangxiang Huang, Jiachao Lu, Shuling Tang, Qin Hu, Qianrong Huang, Fangzhou Guo, Ligen Mo, Jun Yan

  • June 26, 2026

Related Content

Case Report: Hybrid retrograde transcarotid stenting for common carotid artery dissection secondary to acute type A aortic dissection

Psychological distress and caregiver burden among informal caregivers of patients with earthquake-related and stroke-related dependency: a comparative study

A review of the impact of circadian rhythm on motor function in stroke recovery patients