Postoperative periprosthetic fractures associated with compressive osseointegration: a systematic review of the Zimmer Biomet Compress® device - Report - MDSpire
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Systematic Review of Postoperative Periprosthetic Fractures Linked to Compressive Osseointegration with the Zimmer Biomet Compress® Device

  • By

  • Kazuhiko Hashimoto

  • Shunji Nishimura

  • Koji Goto

  • August 22, 2026

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Clinical Report: Systematic Review of Postoperative Periprosthetic Fractures

Overview

This systematic review evaluates the incidence and management of postoperative periprosthetic fractures associated with the Zimmer Biomet Compress® device and compares these outcomes with traditional cemented stems.

Background

Postoperative periprosthetic fractures are a significant concern in massive endoprosthetic reconstruction, particularly following oncological resection or complex trauma. The Zimmer Biomet Compress® device aims to enhance implant fixation through compressive osseointegration.

Data Highlights

No numerical data available in the provided source material.

Key Findings

  • The review included seven studies with a total of 564 cases, comprising 455 oncologic and 109 non-oncologic cases.
  • Methodological quality of included studies was assessed as moderate, with common weaknesses noted.
  • Compressive osseointegration devices have a different failure profile compared to traditional cemented stems.
  • Periprosthetic fractures may occur due to the substantial compressive forces at the bone–implant interface.

Clinical Implications

Surgeons should be aware of the increased risk of periprosthetic fractures associated with the Zimmer Biomet Compress® device. Careful monitoring and management strategies are necessary to address these complications effectively.

Conclusion

This systematic review highlights the need for further research into the management of periprosthetic fractures related to compressive osseointegration devices, as their failure mechanisms differ from traditional implants.

Related Resources & Content

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  2. A Systematic Review of Literature on Mechanical Issues Associated with Hip Spacers, Archives of Orthopaedic and Trauma Surgery, 2022
  3. Reevaluating Assumptions: A Comparison of Early Complications in Native Versus Periprosthetic Distal Femur Fractures and the Impact of Implant Stability, Archives of Orthopaedic and Trauma Surgery, 2025
  4. Osteosarcomas, Onkopedia Guidelines, 2026
  5. Factors Contributing to Mechanical Failures in Total Hip Arthroplasties
  6. Osteosarcomas
  7. Vancouver B3 periprosthetic fractures of the femur: options for treatment | Archives of Orthopaedic and Trauma Surgery | Springer Nature Link
  8. Lower limb osseointegrated prosthetics: are we standing on the edge of a new era? - PMC

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