This study identifies a five-gene prognostic signature linked to KLF10 in glioblastoma-associated macrophages, highlighting its association with tumor progression and poor prognosis.
Background
Glioblastoma (GBM) is the most common and aggressive primary malignant tumor of the adult central nervous system, with a high recurrence rate despite treatment. Tumor-associated macrophages (TAMs) are crucial in GBM progression, yet their characteristics in recurrent GBM remain poorly understood. Understanding the role of KLF10 in TAMs may provide insights into therapeutic strategies targeting the glioblastoma microenvironment.
Data Highlights
Prognostic Signature Genes
KLF10
ZFAND2A
SMAD7
GPR84
ARHGAP12
Key Findings
A five-gene prognostic signature was identified, including KLF10.
KLF10 expression correlates with WHO grade, IDH mutation, and overall survival.
High KLF10 levels predict poor prognosis in glioblastoma patients.
KLF10-associated genes are linked to ECM–receptor interaction and cytokine signaling pathways.
Co-culture with GBM cells upregulated KLF10 in macrophages, enhancing GBM-cell proliferation and invasion.
Clinical Implications
The identification of KLF10 as a prognostic marker in glioblastoma-associated macrophages may inform future therapeutic strategies.
Conclusion
KLF10-high macrophages are associated with glioblastoma progression and represent a potential prognostic marker.
