Variations in Cervical Cancer Incidence Trends Adjusted for Hysterectomy Across Different Age Groups in Puerto Rico, 2001-2023 - Report - MDSpire

Variations in Cervical Cancer Incidence Trends Adjusted for Hysterectomy Across Different Age Groups in Puerto Rico, 2001-2023

  • By

  • Ana P. Ortiz

  • Jeslie M. Ramos-Cartagena

  • Carlos R. Torres-Cintrón

  • Eduardo J. Santiago-Rodríguez

  • Sandra I. García-Camacho

  • Ashish A. Deshmukh

  • Karen J. Ortiz-Ortiz

  • April 29, 2026

  • 0 min

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Clinical Report: Variations in Cervical Cancer Incidence Trends in Puerto Rico

Overview

{'text': 'This study analyzes cervical cancer incidence trends in Puerto Rico from 2001 to 2023, revealing a significant increase among women aged 35 to 49 years, while younger women show a decline potentially linked to HPV vaccination efforts. Overall, hysterectomy-corrected incidence rates remained above 11.5 cases per 100,000 women throughout the study period, indicating a concerning trend.'}

Background

Cervical cancer incidence rates in Puerto Rico are among the highest in the U.S., highlighting a critical public health issue. Despite high HPV vaccination and screening rates, the region has not achieved the World Health Organization's cervical cancer elimination goal. Understanding these trends is essential for guiding public health interventions and improving screening practices.

Data Highlights

{'text': '
YearHysterectomy-Corrected Incidence RateNon-Corrected Incidence Rate
2001-202311.5+Specify data
'}

Key Findings

{'text': '
  • 4636 cervical cancer cases diagnosed in Puerto Rico from 2001 to 2023.
  • Annual hysterectomy-corrected incidence rates exceeded 11.5 cases per 100,000 women.
  • Significant increase in cervical cancer incidence among women aged 35 to 49 years (AAPC, 2.0% - Average Annual Percentage Change).
  • Marked decline in incidence among women younger than 35 years since 2019 (APC, -20.2% - Annual Percentage Change).
  • Stable incidence trends observed for women aged 50 to 64 years throughout the study period.
  • Declines in cervical cancer incidence since 2014, particularly among younger women, possibly linked to HPV vaccination efforts.
'}

Clinical Implications

{'text': 'The findings underscore the need for targeted public health interventions, such as increasing HPV vaccination rates and improving screening adherence, to address the rising cervical cancer incidence among women aged 35 to 49 years.'}

Conclusion

{'text': 'Cervical cancer incidence trends in Puerto Rico indicate a stabilization overall, with significant declines among younger women potentially associated with vaccination efforts. Ongoing surveillance and public health strategies are essential to address the increasing rates in specific age groups, particularly among women aged 35 to 49 years.'}

References

  1. Clarke et al., JAMA Oncology, 2022 -- Trends in Hysterectomy-Corrected Uterine Cancer Mortality and Racial/Ethnic Differences
  2. The Journal of Infectious Diseases, 2023 -- Exploring Trends in HPV-Associated Cancers in Norway: A Focus Beyond Women's Health
  3. American Journal of Epidemiology, 2021 -- Incidence Patterns of Endometrial Cancer in the U.S. by Race/Ethnicity and Age at Diagnosis from 2000 to 2019
  4. ACOG, 2026 -- ACOG Publishes Updated Cervical Cancer Screening Guidance
  5. BMC Medicine, 2024 -- Recent cervical cancer incidence, stage at diagnosis, and mortality trends in Puerto Rico, 2001–2019
  6. the asco post — AACR 2025: Trends in Breast Cancer Incidence for Women Between the Ages of 20 and 49
  7. ACOG Publishes Updated Cervical Cancer Screening Guidance | ACOG
  8. Clinical Validation of a Vaginal Cervical Cancer Screening Self-Collection Method for At-Home Use: A Nonrandomized Clinical Trial | Public Health | JAMA Network Open | JAMA Network
  9. Recent cervical cancer incidence, stage at diagnosis, and mortality trends in Puerto Rico, 2001–2019 | BMC Medicine | Full Text

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